在甲基硝基亚硝基胍诱导的大鼠胃癌模型中，Gedunin 可诱导细胞凋亡并抑制 HMBG1/PI3K/AKT 信号通路。

IF 3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL Archives of Medical Science Pub Date : 2024-03-30 eCollection Date: 2024-01-01 DOI:10.5114/aoms/183651

Weixiang Zhang, Yongshuai Dong, Chenkun Sun

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引用次数: 0

摘要

引言本研究旨在评估天然化合物 gedunin 在 MNNG 诱导的胃癌模型中的抗癌作用：方法：将 54 只大鼠随机分为 6 组，对 MNNG 和 gedunin 的作用进行为期 60 天的研究。第 1-4 组接受 200 毫克/千克的 MNNG（1、10 或 100 毫克/千克），第 5 组仅接受 100 毫克/千克的 Gedunin：结果：低剂量 Gedunin 对 MNNG 诱导的损伤具有抗癌和保护作用，包括减少炎症和细胞凋亡：结论：Gedunin 呈 U 型剂量反应，低剂量具有保护作用，而高剂量则会促进肿瘤生长。

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Gedunin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine.

Introduction: This study aimed to evaluate the anti-cancer effects of gedunin, a natural compound, in a rat model of gastric carcinogenesis induced by MNNG.

Methods: Fifty-four rats were randomly assigned to six groups for a 60-day study on the effects of MNNG and gedunin. Groups 1-4 received 200 mg/kg MNNG (1, 10, or 100 mg/kg), and group 5 had only 100 mg/kg gedunin.

Results: Gedunin at low doses exhibited anti-cancer and protective properties against MNNG-induced damage, including reduced inflammation, and apoptosis.

Conclusions: Gedunin demonstrates a U-shaped dose-response, with low doses offering protection and high doses promoting tumor growth.

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来源期刊

Archives of Medical Science 医学-医学：内科

CiteScore

4.90

自引率

7.90%

发文量

139

审稿时长

1.7 months

期刊介绍： Archives of Medical Science (AMS) publishes high quality original articles and reviews of recognized scientists that deal with all scientific medicine. AMS opens the possibilities for young, capable scientists. The journal would like to give them a chance to have a publication following matter-of-fact, professional review by outstanding, famous medical scientists. Thanks to that they will have an opportunity to present their study results and/or receive useful advice about the mistakes they have made so far. The second equally important aim is a presentation of review manuscripts of recognized scientists about the educational capacity, in order that young scientists, often at the beginning of their scientific carrier, could constantly deepen their medical knowledge and be up-to-date with current guidelines and trends in world-wide medicine. The fact that our educational articles are written by world-famous scientists determines their innovation and the highest quality.