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引用次数: 0
摘要
I 型和 III 型干扰素（IFN-I 和 IFN-III）在针对入侵病原体的早期抗微生物反应中发挥着核心作用。IFN-Is和IFN-IIIs的诱导是由于模式识别受体对病原体相关分子模式（来自微生物）或宿主细胞产生的损伤相关分子模式（DAMPs）的感应。在此，我们回顾了不同病原体如何刺激 IFN-I 和 IFN-III 的表达以及导致 IFN 诱导的信号通路如何受到严格调控的最新进展。我们还总结了在应对严重急性呼吸系统综合征冠状病毒 2 时导致 IFN-I 和 IFN-III 诱导的传感途径方面不断增长的知识。
Regulation of type I and type III interferon induction in response to pathogen sensing
Type I and III interferons (IFN-I and IFN-III) have a central role in the early antimicrobial response against invading pathogens. Induction of IFN-Is and IFN-IIIs arises due to the sensing by pattern recognition receptors of pathogen-associated molecular patterns (from micro-organisms) or of damage-associated molecular patterns (DAMPs; produced by host cells). Here, we review recent developments on how IFN-I and IFN-III expression is stimulated by different pathogens and how the signalling pathways leading to IFN induction are tightly regulated. We also summarise the growing knowledge of the sensing pathways that lead to IFN-I and IFN-III induction in response to severe acute respiratory syndrome coronavirus 2.
期刊介绍：
Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed.
In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.
Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students.
Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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