系统性红斑狼疮疾病活动的潜在生物标志物--系统性免疫炎症指数。

Northern clinics of Istanbul Pub Date : 2024-04-22 eCollection Date: 2024-01-01 DOI:10.14744/nci.2023.90132
Muhammed Recai Akdogan, Meltem Alkan Melikoglu
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引用次数: 0

摘要

目的:利用常规实验室检查准确显示系统性红斑狼疮(SLE)疾病活动的生物标志物在临床上可能具有重要的实用价值。本研究的主要目的是调查中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)和全身免疫炎症指数(SII;中性粒细胞 X 血小板/淋巴细胞)作为系统性红斑狼疮病例疾病活动性潜在生物标志物的情况:在这项病例对照观察研究中,纳入了系统性红斑狼疮病例和人口统计学特征相似的健康对照组。临床评估记录了人口统计学特征、病程和用药情况。系统性红斑狼疮的临床疾病活动性以 SLEDAI 评分进行评估。在实验室评估方面,记录了红细胞沉降率(ESR)、C反应蛋白(CRP)和C3-C4水平以及抗dsDNA阳性率。根据参与者的同期全血细胞计数(CBC),计算出 NLR、PLR 和 SII。分析了临床和实验室数据之间的相关性:本次调查共纳入 68 名系统性红斑狼疮患者(64 名女性,8 名男性)和 69 名对照组患者(65 名女性,4 名男性)。病例和对照组的人口统计学特征相似。从统计学角度看,系统性红斑狼疮患者的血沉、CRP、NLR、PLR 和 SII 评分均高于对照组(p 结论:系统性红斑狼疮患者的血沉、CRP、NLR、PLR 和 SII 评分均高于对照组:在我们的研究中,系统性红斑狼疮患者的 CBC 指数高于健康对照组。SII 与疾病活动性密切相关,对疾病状态有很强的鉴别能力,可作为支持系统性红斑狼疮临床评估的生物标志物。
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A potential biomarker of disease activity in systemic lupus erythematosus, systemic immune-inflammation index.

Objective: Biomarkers using routine laboratory tests accurately presenting systemic lupus erythematosus (SLE) disease activity may have important practical values in clinical settings. The primary purpose of this study was to investigate neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII; neutrophil X platelet/lymphocyte) as potential biomarkers of disease activity in cases with SLE.

Methods: In this case-control observational study, cases with SLE and demographically similar healthy controls were included. For clinical evaluation demographic features, disease duration and drugs were recorded. SLE clinical disease activity was assessed with SLEDAI scores. For laboratory assessments; erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and C3-C4 levels and anti-dsDNA positivity were recorded. Based on the simultaneous complete blood count (CBC) of the participants NLR, PLR and SII were calculated. The correlation between clinical and laboratory data was analyzed.

Results: 68 cases with SLE (64 women, 8 men) and 69 controls (65 women, 4 men) were included in this investigation. The demographic features of the cases and controls were similar. ESR, CRP, NLR, PLR and SII scores were statistically higher in cases with SLE than controls (p<0.000). Statistically significant positive correlations between SLEDAI and NLR, PLR and SII scores were demonstrated (p=0.01, r=0.505; 0.414; 0.698, respectively). We determined a cut-off value of SII as 681,3 presenting 77% sensitivity and 76% specificity to discriminate no-mild disease activity and moderate-higher SLE disease activity status. The SII cut-off value was determined as 681,3 presenting 77% sensitivity and 76% specificity (p<0.000, and AUC=0.930).

Conclusion: CBC indices were shown to be higher in cases with SLE than healthy controls in our study. By presenting a strong correlation with disease activity and discriminating ability of disease status, SII might serve as a biomarker supporting clinical evaluation in SLE.

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