ANTIOXIDANT POTENTIAL OF PERITONEAL FLUID IN OVARIAN CANCER

In ovarian cancer, peritoneal fluid is an active participant in carcinogenesis. The study included 48 patients aged 25–74 years with histologically confirmed ovarian cancer and benign ovarian neoplasms. Using an original technique based on the method of enhanced kinetic chemiluminescence, the antioxidant profiles of peritoneal fluid with ovarian cancer and benign neoplasms were evaluated. In the peritoneal fluid, the antioxidant capacity significantly increased in the series benign tumors > highly differentiated > moderately and poorly differentiated adenocarcinomas, leading to a state of antioxidant excess in the case of moderately and poorly differentiated adenocarcinomas. Thus, in ovarian cancer, tumor progression leads to a shift towards an excess of antioxidants, possibly due to metabolites of the tumor itself.