治疗突发性感音神经性听力损失的鸡尾酒疗法

Anusha Venkatraman, Santosh Balasaheb Mane, Kamalika Purkayastha Roy, Poonam Khairnar
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摘要

本研究旨在评估鸡尾酒疗法治疗突发性感音神经性听力损失(SSNHL)的疗效。前瞻性观察研究。三甲医院。35名符合纳入标准的突发性感音神经性听力损失患者。鸡尾酒疗法包括鼓室内类固醇注射、口服类固醇、伐昔洛韦和喷托维林。主要结果是纯音测听(PTA)从治疗前到治疗后 3 个月的变化,按照改良西格尔标准进行分析。在 35 名患者中,26 人(74.2%)在 3 个月的随访中听力有所改善(包括完全恢复和部分恢复)。PTA 的平均改善幅度为 22.56 分贝(标准差 = 18.4)。然而,计算得出的治疗效果和听力恢复比较的几率比(OR)均为 1.0,置信区间较宽,表明听力改善组和听力未改善组之间没有显著的统计学差异。鸡尾酒疗法显示出对 SSNHL 患者听力恢复的潜在益处,尤其是对初始听力损失不太严重的病例。尽管如此,比较分析中没有统计学意义上的显著差异突出表明,需要进行更大规模的随机对照试验来证实这些发现。
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Cocktail regimen in treatment of sudden sensorineural hearing loss
This study aims to evaluate the efficacy of a cocktail regimen for the treatment of sudden sensorineural hearing loss (SSNHL). A prospective observational study. Tertiary care hospital. Thirty-five patients diagnosed with SSNHL who met the inclusion criteria. The cocktail regimen included intratympanic steroid injections, oral steroids, valacyclovir, and pentoxifylline. The primary outcome was the change in Pure Tone Audiometry (PTA) from pre-treatment to 3 months post-treatment, analyzed by Modified Siegel’s criteria. Of the 35 patients, 26 (74.2%) showed hearing improvement (including complete and partial recovery) at the 3-month follow-up. The mean improvement in PTA was 22.56 dB (SD = 18.4). However, the calculated odds ratios (OR) for treatment efficacy and hearing recovery comparisons were 1.0, with wide confidence intervals, indicating no statistically significant differences between improved and not improved groups. The cocktail regimen showed potential benefits for hearing recovery in SSNHL patients, particularly in cases with less severe initial hearing loss. Nevertheless, the absence of a statistically significant difference in the comparative analyses underscores the need for larger, randomized controlled trials to substantiate these findings.
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