使用改性壳聚糖吸附材料同时去除水混合物中的七种药物化合物

Macromol Pub Date : 2024-05-11 DOI:10.3390/macromol4020018
M. Papageorgiou, Konstantinos N. Maroulas, E. Evgenidou, D. Bikiaris, G. Kyzas, Dimitra A Lambropoulou
{"title":"使用改性壳聚糖吸附材料同时去除水混合物中的七种药物化合物","authors":"M. Papageorgiou, Konstantinos N. Maroulas, E. Evgenidou, D. Bikiaris, G. Kyzas, Dimitra A Lambropoulou","doi":"10.3390/macromol4020018","DOIUrl":null,"url":null,"abstract":"Pharmaceuticals are used to improve the lives of people across the globe. The high demand for their fabrication and use causes a very serious environmental threat since their presence is ubiquitous in aqueous matrices. For this reason, the synthesis, characterisation, and efficiency of three chitosan-based materials to eliminate pharmaceutical mixtures from aqueous solutions were examined in the present study. The target mixture comprised seven widely used drugs: carbamazepine, cyclophosphamide, adefovir, levofloxacin, metronidazole, glibenclamide, and trimethoprim. The grafting of poly(ethylene imine) and poly(acrylamide) on the chitosan structure allowed its physical characteristics to be controlled. An adsorption assessment was performed at different pH values, and it was concluded that pH = 4 was the optimum value. The adsorption kinetics revealed that the adsorption of a drug mixture involves a combination of physical and chemical adsorption. The adsorption process appeared to be finished after 1 h for all compounds of the studied mixture, with CS-AMI exhibiting the fastest kinetics. Mass adsorption experiments were also carried out to determine its effects. Overall, the grafting process significantly increased the adsorption capacity over the pristine material. Specifically, the highest capacity increase for CS-PEI was ~220% for carbamazepine, and for CS-AMI, it was 158% for trimethoprim. FT-IR, SEM, and XRD were used for the characterisation of the polymers. Based on the findings, the three materials are suggested as very effective adsorbents for the elimination of medicine residues from aqueous matrices.","PeriodicalId":510296,"journal":{"name":"Macromol","volume":" 953","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Simultaneous Removal of Seven Pharmaceutical Compounds from a Water Mixture Using Modified Chitosan Adsorbent Materials\",\"authors\":\"M. Papageorgiou, Konstantinos N. Maroulas, E. Evgenidou, D. Bikiaris, G. Kyzas, Dimitra A Lambropoulou\",\"doi\":\"10.3390/macromol4020018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Pharmaceuticals are used to improve the lives of people across the globe. The high demand for their fabrication and use causes a very serious environmental threat since their presence is ubiquitous in aqueous matrices. For this reason, the synthesis, characterisation, and efficiency of three chitosan-based materials to eliminate pharmaceutical mixtures from aqueous solutions were examined in the present study. The target mixture comprised seven widely used drugs: carbamazepine, cyclophosphamide, adefovir, levofloxacin, metronidazole, glibenclamide, and trimethoprim. The grafting of poly(ethylene imine) and poly(acrylamide) on the chitosan structure allowed its physical characteristics to be controlled. An adsorption assessment was performed at different pH values, and it was concluded that pH = 4 was the optimum value. The adsorption kinetics revealed that the adsorption of a drug mixture involves a combination of physical and chemical adsorption. The adsorption process appeared to be finished after 1 h for all compounds of the studied mixture, with CS-AMI exhibiting the fastest kinetics. Mass adsorption experiments were also carried out to determine its effects. Overall, the grafting process significantly increased the adsorption capacity over the pristine material. Specifically, the highest capacity increase for CS-PEI was ~220% for carbamazepine, and for CS-AMI, it was 158% for trimethoprim. FT-IR, SEM, and XRD were used for the characterisation of the polymers. Based on the findings, the three materials are suggested as very effective adsorbents for the elimination of medicine residues from aqueous matrices.\",\"PeriodicalId\":510296,\"journal\":{\"name\":\"Macromol\",\"volume\":\" 953\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Macromol\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/macromol4020018\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromol","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/macromol4020018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

药品用于改善全球人民的生活。对其制造和使用的高需求造成了非常严重的环境威胁,因为它们在水基质中无处不在。为此,本研究考察了三种壳聚糖基材料的合成、表征和从水溶液中去除药物混合物的效率。目标混合物包括七种广泛使用的药物:卡马西平、环磷酰胺、阿德福韦酯、左氧氟沙星、甲硝唑、格列本脲和曲美普林。在壳聚糖结构上接枝聚(乙烯亚胺)和聚(丙烯酰胺)可控制其物理特性。在不同的 pH 值下进行了吸附评估,得出的结论是 pH = 4 是最佳值。吸附动力学表明,药物混合物的吸附涉及物理吸附和化学吸附的结合。所研究混合物中的所有化合物似乎都在 1 小时后完成了吸附过程,其中 CS-AMI 的吸附动力学速度最快。为了确定其效果,还进行了质量吸附实验。总的来说,与原始材料相比,接枝过程大大提高了吸附容量。具体来说,CS-PEI 对卡马西平的吸附容量提高了约 220%,CS-AMI 对曲美普林的吸附容量提高了 158%。傅立叶变换红外光谱、扫描电子显微镜和 XRD 被用于聚合物的表征。根据研究结果,这三种材料可作为非常有效的吸附剂,用于消除水基中的药物残留。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Simultaneous Removal of Seven Pharmaceutical Compounds from a Water Mixture Using Modified Chitosan Adsorbent Materials
Pharmaceuticals are used to improve the lives of people across the globe. The high demand for their fabrication and use causes a very serious environmental threat since their presence is ubiquitous in aqueous matrices. For this reason, the synthesis, characterisation, and efficiency of three chitosan-based materials to eliminate pharmaceutical mixtures from aqueous solutions were examined in the present study. The target mixture comprised seven widely used drugs: carbamazepine, cyclophosphamide, adefovir, levofloxacin, metronidazole, glibenclamide, and trimethoprim. The grafting of poly(ethylene imine) and poly(acrylamide) on the chitosan structure allowed its physical characteristics to be controlled. An adsorption assessment was performed at different pH values, and it was concluded that pH = 4 was the optimum value. The adsorption kinetics revealed that the adsorption of a drug mixture involves a combination of physical and chemical adsorption. The adsorption process appeared to be finished after 1 h for all compounds of the studied mixture, with CS-AMI exhibiting the fastest kinetics. Mass adsorption experiments were also carried out to determine its effects. Overall, the grafting process significantly increased the adsorption capacity over the pristine material. Specifically, the highest capacity increase for CS-PEI was ~220% for carbamazepine, and for CS-AMI, it was 158% for trimethoprim. FT-IR, SEM, and XRD were used for the characterisation of the polymers. Based on the findings, the three materials are suggested as very effective adsorbents for the elimination of medicine residues from aqueous matrices.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Application of Annealed Bambara Starch as a Stabilizer in Ice Cream Production New Trends in Composite Coagulants for Water and Wastewater Treatment Pulmonary Drug Delivery through Responsive Materials Peach Gum Polysaccharide as an Additive for Thermoplastic Starch to Produce Water-Soluble Films Fabrication and Characterization of Collagen–Magnetic Particle Composite Microbeads for Targeted Cell Adhesion and Proliferation
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1