Georgios I. Psarras, Ariadni Zianna, A. Hatzidimitriou, G. Psomas
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引用次数: 0
摘要
在 1,10-菲罗啉(phen)或其衍生物 2,9-二甲基-1-菲罗啉(neoc)作为共配位体存在或不存在的情况下,合成了 3,5-二溴水杨醛(3,5-diBr-saloH)的三种中性镍(II)配合物、10-菲罗啉(neoc)作为共配位体的情况下合成了[Ni(3,5-diBr-salo)2(neoc)](络合物 1)、[Ni(3,5-diBr-salo)2(phen)](络合物 2)和[Ni(3,5-diBr-salo)2(H2O)2](络合物 3),并通过各种技术对它们进行了表征。单晶 X 射线晶体学确定了[Ni(3,5-diBr-salo)2(neoc)]的晶体结构。根据所采用的研究技术,这些复合物以插层方式与小牛胸腺 DNA 紧密结合。此外,化合物 1-3 还能与人和牛血清白蛋白紧密且可逆地结合。
Coordination Compounds of Nickel(II) with 3,5–Dibromo–Salicylaldehyde: Structure and Interaction with Biomolecules
Three neutral nickel(II) complexes of 3,5–dibromo–salicylaldehyde (3,5–diBr–saloH) were synthesized in the presence or absence of 1,10–phenanthroline (phen) or its derivative 2,9–dimethyl–1,10–phenanthroline (neoc) as co–ligands, namely [Ni(3,5–diBr–salo)2(neoc)] (complex 1), [Ni(3,5–diBr–salo)2(phen)] (complex 2) and [Ni(3,5–diBr–salo)2(H2O)2] (complex 3), and were characterized by various techniques. The crystal structure of [Ni(3,5–diBr–salo)2(neoc)] was determined by single-crystal X-ray crystallography. According to employed studying techniques, the complexes interact tightly with calf-thymus DNA by an intercalative fashion. Furthermore, compounds 1–3 bind tightly and reversibly to human and bovine serum albumin.