红姜根茎提取物肥皂作为抗菌剂的配制和评估

Q2 Pharmacology, Toxicology and Pharmaceutics International Journal of Applied Pharmaceutics Pub Date : 2024-05-07 DOI:10.22159/ijap.2024v16i3.49550
Novi Nurleni, Arie Firdiawan, Agnes Rendowaty, Resti Kurniasari
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引用次数: 0

摘要

目的:目前的研究工作旨在将红姜制成一种稳定的肥皂制剂:目前的研究工作旨在将红姜配制成一种稳定的肥皂制剂,作为抗菌剂有效且可长期安全使用:方法:采用浸渍法提取红姜根茎。在配方中,提取物的浓度各不相同,其中配方 I (FI) 为 3%,配方 II (FII) 为 5%,配方 III (FIII) 为 7%,配方 IV (FIV) 为 0%。制剂的评估包括感官评估、均匀性、pH 值、粘度和流动性、密度、泡沫高度和稳定性等测试,以及采用琼脂扩散法对金黄色葡萄球菌 ATCC 25932 和大肠杆菌 ATCC 25922 的抗菌活性测试:萃取率为 2.38%。在 28 天的评价中,三种肥皂配方均表现出良好的稳定性(显著性>0.05),表明在贮藏期间没有发生显著变化,三种连续配方对金黄色葡萄球菌 ATCC 25923 的抑菌力分别为 9.对大肠杆菌 ATCC 25922 的抑菌力分别为 6.01±0.6;10.32±0.4;12.58±0.6(mm):评价结果表明,所有配方在储存期间都具有良好的稳定性。红姜提取物浓度的变化会影响对试验细菌的抑制能力。与其他配方相比,提取物含量为 7% 的 F III 具有更好的抗菌活性。
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FORMULATION AND EVALUATION OF RED GINGER RHIZOME EXTRACT SOAP AS AN ANTIBACTERIAL
Objective: Current research work aimed to develop a formulation of red ginger into a stable soap preparation, effective as an antibacterial and safe for long-term use. Methods: The maceration method was used to extract red ginger rhizome. In the formulation, there are variations in the concentration of the extract, where Formulation I (FI) 3%, Formulation II (FII) 5%, Formulation III (FIII) 7%, and Formulation IV (FIV) 0%. The evaluation of the preparation includes tests such as sensory evaluation, homogeneity, pH, viscosity and flow properties, density, foam height, and stability, as well as antibacterial activity using the agar diffusion method against Staphylococcus aureus ATCC 25932 and Escherichia coli ATCC 25922. Results: The percentage of extract yield obtained was 2.38%. All three formulations of soap have shown good stability during the 28-day evaluation (significant>0.05), indicating no significant changes during storage, and the inhibitory power of Staphylococcus aureus ATCC 25923 bacteria in the three successive formulations was 9.03±0.4; 12.21±0.3; 15.26±0.4 (mm) respectively, while that of Escherichia coli ATCC 25922 was 6.01±0.6; 10.32±0.4; 12.58±0.6 (mm). Conclusion: The evaluation results, all formulations have good stability during storage. The variation in concentration of red ginger extract will affect the inhibitory power against test bacteria. F III, with an extract content of 7% has better antibacterial activity compared to other formulations.
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来源期刊
International Journal of Applied Pharmaceutics
International Journal of Applied Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
1.40
自引率
0.00%
发文量
219
期刊介绍: International Journal of Applied Pharmaceutics (Int J App Pharm) is a peer-reviewed, bimonthly (onward March 2017) open access journal devoted to the excellence and research in the pure pharmaceutics. This Journal publishes original research work that contributes significantly to further the scientific knowledge in conventional dosage forms, formulation development and characterization, controlled and novel drug delivery, biopharmaceutics, pharmacokinetics, molecular drug design, polymer-based drug delivery, nanotechnology, nanocarrier based drug delivery, novel routes and modes of delivery; responsive delivery systems, prodrug design, development and characterization of the targeted drug delivery systems, ligand carrier interactions etc. However, the other areas which are related to the pharmaceutics are also entertained includes physical pharmacy and API (active pharmaceutical ingredients) analysis. The Journal publishes original research work either as a Original Article or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication in the Journal.
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