全面回顾一种特殊的皮肤损伤:发病机制、诱因和当前治疗方案

T. Kukreja, Arushi Saloki, S. Saraf
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摘要

根据定义,开放性损伤是指皮肤和深层组织连续性的任何严重破坏。由于挫伤是已愈合的损伤,因此上述术语不适用于它们。伤害分类对于治疗和医疗法律目的都至关重要。烧伤与其他损伤类似,都需要遵循相同的基本原则进行治疗和护理,但它们的不同之处在于,烧伤对患者的整体健康影响更大,对患者的最终存活、畸形发展和康复至关重要。治疗烧伤一直是烧伤专科医生的职责。长期以来,人们一直建议采用局部和全身疗法治疗烧伤并尽量减少烧伤疤痕。本综述总结了由各种物理和化学制剂引起的烧伤的治疗方法,这些方法需要采用与治疗其他外伤完全不同的独特疗法。其他急性损伤导致的全部失血会导致休克,而大面积烧伤则会因毛细血管通透性增加而导致血浆大量流失,进而引起窘迫。与大多数其他创伤相比,烧伤最初是无菌的,但由于烧伤病人的免疫功能低下,感染常常导致严重烧伤病人死亡。我们在这篇综述中讨论了烧伤的病理生理学、初级护理疗法、用于损伤愈合疗法的纳米材料以及损伤愈合过程中的各种纳米粒子。
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A Comprehensive Review of a particular Skin Injury: Pathogenesis, triggers, and current Treatment Options
By definition, an open injury is any severe break in the continuity of the skin and deep tissue. Because contusions are healed injuries, the term given above does not apply to them. The classification of injuries is essential for both therapeutic and medico-legal purposes. Burn injuries are comparable to other injuries in that they require the same basic principles for healing and care, but they differ in that they have a greater impact on the patient's overall health and are essential to the patient's eventual survival, the development of deformity, and rehabilitation. Treatment of burn injuries has always been the responsibility of burn specialists. Both local and systemic therapy have long been advised for treating burn injuries and minimizing burn scars. This review summarizes the treatment of burn injuries brought on by a variety of physical and chemical agents requires unique regimens that are completely different from those used to treat any other traumatic injuries. Other acute injuries that undergo entire blood loss result in shock, but major burns that experience significant plasma loss due to increased capillary permeability result in distress. Burn injuries are initially sterile compared to the majority of other injuries, however, due to the immunocompromised state of burn patients and injury infection frequently ends in death in serious burns. We have discussed the pathophysiology, primary care therapies, nanomaterials used in injury healing therapy and various nanoparticles in injury healing process for burn injuries in this review.
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