人工智能在药物发现革命中的作用

IF 6.3 3区 综合性期刊 Q1 Multidisciplinary Fundamental Research Pub Date : 2025-05-01 Epub Date: 2024-05-09 DOI:10.1016/j.fmre.2024.04.021
Ashfaq Ur Rehman , Mingyu Li , Binjian Wu , Yasir Ali , Salman Rasheed , Sana Shaheen , Xinyi Liu , Ray Luo , Jian Zhang
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引用次数: 0

摘要

人工智能(AI)在医学中的应用,特别是通过机器学习(ML),标志着药物发现的重大进展。人工智能在缩小疾病理解和确定潜在治疗剂之间的差距方面发挥着强大的催化剂作用。本文综述了人工智能的最新进展及其在药物发现中的应用。我们研究了药物发现过程的各个阶段,从疾病识别开始,包括诊断、目标识别、筛选和先导发现。人工智能分析大量数据集和识别模式的能力在这些阶段至关重要,可以提高疾病识别、药物发现和临床试验管理方面的预测和效率。强调了人工智能在加速药物开发方面的作用,强调了其分析大量数据的潜力,从而减少了与新药市场引入相关的时间和成本。讨论了数据质量、算法训练和伦理考虑的重要性,特别是在临床试验期间的患者数据处理中。考虑到这些因素,人工智能有望改变药物开发,为患者和社会带来重大利益。
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Role of artificial intelligence in revolutionizing drug discovery
The application of artificial intelligence (AI) in medicine, particularly through machine learning (ML), marked a significant progression in drug discovery. AI acts as a powerful catalyst in narrowing the gap between disease understanding and the identification of potential therapeutic agents. This review provides an inclusive summary of the latest advancements in AI and its application in drug discovery. We examine the various stages of the drug discovery process, starting from disease identification and encompassing diagnosis, target identification, screening, and lead discovery. AI's capability to analyze extensive datasets and discern patterns is essential in these stages, enhancing predictions and efficiencies in disease identification, drug discovery, and clinical trial management. The role of AI in expediting drug development is emphasized, highlighting its potential to analyze vast data volumes, thus reducing the time and costs associated with new drug market introduction. The importance of data quality, algorithm training, and ethical considerations, especially in patient data handling during clinical trials, is addressed. By considering these factors, AI promises to transform drug development, offering significant benefits to patients and society.
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来源期刊
Fundamental Research
Fundamental Research Multidisciplinary-Multidisciplinary
CiteScore
4.00
自引率
1.60%
发文量
294
审稿时长
79 days
期刊介绍:
期刊最新文献
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