肠道机械免疫学:通过物理线索形成免疫反应

IF 13.7 1区 生物学 Q1 BIOLOGY Physics of Life Reviews Pub Date : 2024-05-13 DOI:10.1016/j.plrev.2024.05.003
Ziwei Wang , Ning Xie , Xiru Liang , Qiuai Shu , Yijie Hong , Haitao Shi , Jinhai Wang , Daiming Fan , Na Liu , Feng Xu
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引用次数: 0

摘要

肠道免疫系统体现了肠道粘膜屏障、宿主免疫细胞和肠道微生物群之间复杂的相互作用。这些成分存在于以各种物理线索(如压缩、拉伸、剪切应力、硬度和粘弹性)为特征的动态环境中。在特定病理条件下,这些物理线索会发生变化。鉴于其动态性质,理解这些物理线索对肠道免疫系统的具体影响对于肠道免疫相关疾病的病理和治疗研究至关重要。本综述旨在讨论物理线索如何通过影响肠道粘膜屏障、宿主免疫细胞和肠道微生物群来影响肠道免疫学,并将这一概念定义为肠道机械免疫学。本综述旨在强调,加强对肠道机械免疫学的了解不仅对肠道疾病,而且对肠道外疾病都有治疗意义。
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Gut mechanoimmunology: Shaping immune response through physical cues

The gut immune system embodies a complex interplay between the gut mucosal barrier, the host's immune cells, and gut microbiota. These components exist within a dynamic environment characterized by a variety of physical cues, e.g., compression, tension, shear stress, stiffness, and viscoelasticity. The physical cues can be modified under specific pathological conditions. Given their dynamic nature, comprehending the specific effects of these physical cues on the gut immune system is critical for pathological and therapeutic studies of intestinal immune-related diseases. This review aims to discuss how physical cues influence gut immunology by affecting the gut mucosal barrier, host immune cells, and gut microbiota, defining this concept as gut mechanoimmunology. This review seeks to highlight that an enhanced understanding of gut mechanoimmunology carries therapeutic implications, not only for intestinal diseases but also for extraintestinal diseases.

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来源期刊
Physics of Life Reviews
Physics of Life Reviews 生物-生物物理
CiteScore
20.30
自引率
14.50%
发文量
52
审稿时长
8 days
期刊介绍: Physics of Life Reviews, published quarterly, is an international journal dedicated to review articles on the physics of living systems, complex phenomena in biological systems, and related fields including artificial life, robotics, mathematical bio-semiotics, and artificial intelligent systems. Serving as a unifying force across disciplines, the journal explores living systems comprehensively—from molecules to populations, genetics to mind, and artificial systems modeling these phenomena. Inviting reviews from actively engaged researchers, the journal seeks broad, critical, and accessible contributions that address recent progress and sometimes controversial accounts in the field.
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