大剂量维生素 C 联合环氧化酶-2 抑制剂治疗严重放射性直肠炎

Q1 Health Professions Radiation Medicine and Protection Pub Date : 2024-06-01 DOI:10.1016/j.radmp.2024.05.002

Han Wu , Miaomiao Liu , Huangang Jiang , Hui Xu , Jin Peng , Jing Dai , Fuxiang Zhou

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摘要

方法对4例重度放射性直肠炎患者进行大剂量维生素C（VC，12-24 g/d，iv）联合环氧化酶-2（cyclooxygenase-2，COX-2）抑制剂治疗。结论大剂量 VC 联合治疗重度放射性直肠炎安全有效。

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Treatment of severe radiation proctitis with high dosage of vitamin C in combination with cyclooxygenase-2 inhibitor

Objective

To explore the new treatment strategies for radiation proctitis, which is the most common complication of pelvic tumor malignancies.

Methods

Four cases of patients with severe radiation proctitis were treated with high-dosage vitamin C (V_C, 12–24 g/d, iv) combined with cyclooxygenase-2 (cyclooxygenase-2, COX-2) inhibitors.

Results

For these four cases, the diarrhea, hematochezia, tenesmus, pain, and other symptoms were significantly improved. The edema of the rectal wall is also significantly improved in the imaging review.