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Analysis on occupational exposure associated cancer risk in medical X-ray diagnostic workers in Jiangsu province, China, 2011–2021: A cohort study
Q1 Health Professions Pub Date : 2025-04-01 DOI: 10.1016/j.radmp.2025.03.001
Xindi Wei , Wei Chen , Jin Wang , Zihao Zhang , Yuji Miao , Yuanyuan Zhou , Xiangyong Fan , Jinhan Wang , Yeqing Gu

Objective

To investigate the relationship between occupational X-ray exposure and cancer risk in medical X-ray diagnostic workers, a cohort study was conducted in medical X-ray diagnostic workers in Jiangsu province, China, based on Chinese Medical X-ray Workers Cohort, in order to provide scientific evidence for the improvement of occupational radiation protection in medical X-ray diagnostic workers.

Methods

From 2011 to 2021, a retrospective cohort study was conducted in 2,984 medical X-ray diagnostic workers who worked in the radiology departments of all hospitals in Jiangsu during 1950–1980 and were alive by June 30, 2011 (radiation group) and 2,601 medical workers who worked in other departments of the same hospitals during the same period and were alive by June 30, 2011 (control group). Basic information and cancer incidence were collected from the study participants. The person-years of observation in the study participants during 2011–2021 was calculated. Cox regression model was used to calculate the relative risk for cancers such as solid cancer, lung cancer, and lymphomas in the radiation group after adjustment for sex, age, year of birth, and year to start working, and stratified analyses on the risks for total cancer and solid cancer in the radiation group were performed for confounders such as sex.

Results

The total number of person-years of follow-up was 52,327, and the loss to follow-up rate was 3.15%. A total of 544 cancer cases were detected in follow-up during this period. Compared with the control group, the hazard ratio (HR) of total cancer was 1.13 (95% CI: 0.93–1.37), and the HR of solid cancer was 1.11 (95% CI: 0.91–1.36) in the radiation group. Compared with the control group, the radiation group had significantly higher risk for lymphoma (HR ​= ​10.36, 95% CI:1.27–84.27). Stratified analyses showed that the medical X-ray workers who started to working before 1970 had higher risks for solid cancer (HR ​= ​1.26, 95% CI:1.01–1.59) and total cancer (HR ​= ​1.29, 95% CI:1.04–1.62) compared with those who started working after 1970.

Conclusion

The risk for lymphoma was high in the medical X-ray workers in Jiangsu, suggesting that it is necessaryt to strengthen the occupational radiation protection for medical X-ray workers.
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引用次数: 0
Therapeutic effects of non-preconditioning allogeneic hematopoietic stem cell transplantation on acute radiation injury
Q1 Health Professions Pub Date : 2025-04-01 DOI: 10.1016/j.radmp.2025.01.001
Liren Qian, Yu Liu, Xiaoxuan Lu, Jiaxin Liu

Objective

To investigate the therapeutic effects of non-preconditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT) on acute radiation injury.

Methods

Irradiated mice were randomly divided into six groups, i.e., the control group, the irradiation group, and groups treated with transplantation at 0, 4, 8, and 12 ​d post-irradiation, with 10 mice in each group. The survival rates, graft versus host disease (GvHD), and chimerism of the mice in various groups were assessed.

Results

The maximum 60 ​d survival rate of mice treated with non-preconditioning allo-HSCT at 0, 4, and 8 ​d after 6.5 ​Gy radiation increased to 70% and 80%, respectively, significantly higher than that of mice that did not undergo non-preconditioning allo-HSCT (50%; P < 0.05). The survival rate of mice undergoing non-preconditioning allo-HSCT at 12 ​d after radiation no longer significantly decreased. No pronounced GvHD was observed in the mice. The mice treated with non-preconditioning allo-HSCT at 0, 4, 8, and 12 ​d post-radiation exhibited chimerism rates of 80.53%, 92.75%, 80.46%, and 80.87%, respectively, at 56 ​d post-transplantation. At 28 ​d after non-preconditioning allo-HSCT, the donor-derived fluorescent cells in recipient mice increased significantly (P ​< ​0.05).

Conclusions

This study will fill the gap in the field of radiation medicine and hematopoietic stem cell transplantation (HSCT) by addressing challenges that hinder the application of traditional HSCT, such as donor shortage, toxicity of preconditioning chemotherapy, the occurrence of GvHD, and the administration of post-transplantation immunosuppressants. The results would provide theoretical value and application prospects for research on radiation medicine and HSCT.
{"title":"Therapeutic effects of non-preconditioning allogeneic hematopoietic stem cell transplantation on acute radiation injury","authors":"Liren Qian,&nbsp;Yu Liu,&nbsp;Xiaoxuan Lu,&nbsp;Jiaxin Liu","doi":"10.1016/j.radmp.2025.01.001","DOIUrl":"10.1016/j.radmp.2025.01.001","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the therapeutic effects of non-preconditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT) on acute radiation injury.</div></div><div><h3>Methods</h3><div>Irradiated mice were randomly divided into six groups, i.e., the control group, the irradiation group, and groups treated with transplantation at 0, 4, 8, and 12 ​d post-irradiation, with 10 mice in each group. The survival rates, graft versus host disease (GvHD), and chimerism of the mice in various groups were assessed.</div></div><div><h3>Results</h3><div>The maximum 60 ​d survival rate of mice treated with non-preconditioning allo-HSCT at 0, 4, and 8 ​d after 6.5 ​Gy radiation increased to 70% and 80%, respectively, significantly higher than that of mice that did not undergo non-preconditioning allo-HSCT (50%; <em>P &lt;</em> 0.05). The survival rate of mice undergoing non-preconditioning allo-HSCT at 12 ​d after radiation no longer significantly decreased. No pronounced GvHD was observed in the mice. The mice treated with non-preconditioning allo-HSCT at 0, 4, 8, and 12 ​d post-radiation exhibited chimerism rates of 80.53%, 92.75%, 80.46%, and 80.87%, respectively, at 56 ​d post-transplantation. At 28 ​d after non-preconditioning allo-HSCT, the donor-derived fluorescent cells in recipient mice increased significantly (<em>P</em> ​&lt; ​0.05).</div></div><div><h3>Conclusions</h3><div>This study will fill the gap in the field of radiation medicine and hematopoietic stem cell transplantation (HSCT) by addressing challenges that hinder the application of traditional HSCT, such as donor shortage, toxicity of preconditioning chemotherapy, the occurrence of GvHD, and the administration of post-transplantation immunosuppressants. The results would provide theoretical value and application prospects for research on radiation medicine and HSCT.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 103-106"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge and perceptions of Moroccan medical physicists regarding the contribution of artificial intelligence in medical imaging and radiotherapy
Q1 Health Professions Pub Date : 2025-04-01 DOI: 10.1016/j.radmp.2025.02.003
S. Semghouli , M. El Fahssi , M. Zerfaoui , A. Hadaoui , B. Amaoui

Objective

To explore the perception of Moroccan medical physicists regarding the use of Artificial Intelligent (AI) in medical imaging and in radiotherapy.

Methods

A standardized anonymous questionnaire of 24 questions was sent to our target population, medical physics PhDs (G1), medical physics PhD students (G2) and Master's students in medical physics (G3). It covers their knowledge and skills in artificial intelligence, their training in the field as well as their practices, and the threats and limits of AI.

Results

The three groups shared almost the same opinions on the training program for medical physicists and that more than 87.50% of the three groups thought that AI should be taught in their training program. Over 81.3% of the three groups share the same opinion regarding the role of AI in medical physicists. They strongly agreed or agreed that they were ready to learn and apply AI in their practice. In addition, 50% of G1s, 68.8% of G2s, and 87.5% of G3s strongly agree or agree that more and more tasks, such as quality control and treatment planning, will be performed by AI. Furthermore, 62.5% of G1s, 81.3% of G2s, and 75.0% of G3s strongly agree or agree that AI solutions will make it possible to considerably reduce radiation doses in the field of imaging in the next few years.

Conclusion

The reinforcement of continuous training and the introduction of training modules in the curriculum of Moroccan medical physicists’ as well as a broad awareness of the benefits of AI are guarantees for the successful implementation of this innovative technology.
{"title":"Knowledge and perceptions of Moroccan medical physicists regarding the contribution of artificial intelligence in medical imaging and radiotherapy","authors":"S. Semghouli ,&nbsp;M. El Fahssi ,&nbsp;M. Zerfaoui ,&nbsp;A. Hadaoui ,&nbsp;B. Amaoui","doi":"10.1016/j.radmp.2025.02.003","DOIUrl":"10.1016/j.radmp.2025.02.003","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the perception of Moroccan medical physicists regarding the use of Artificial Intelligent (AI) in medical imaging and in radiotherapy.</div></div><div><h3>Methods</h3><div>A standardized anonymous questionnaire of 24 questions was sent to our target population, medical physics PhDs (G1), medical physics PhD students (G2) and Master's students in medical physics (G3). It covers their knowledge and skills in artificial intelligence, their training in the field as well as their practices, and the threats and limits of AI.</div></div><div><h3>Results</h3><div>The three groups shared almost the same opinions on the training program for medical physicists and that more than 87.50% of the three groups thought that AI should be taught in their training program. Over 81.3% of the three groups share the same opinion regarding the role of AI in medical physicists. They strongly agreed or agreed that they were ready to learn and apply AI in their practice. In addition, 50% of G1s, 68.8% of G2s, and 87.5% of G3s strongly agree or agree that more and more tasks, such as quality control and treatment planning, will be performed by AI. Furthermore, 62.5% of G1s, 81.3% of G2s, and 75.0% of G3s strongly agree or agree that AI solutions will make it possible to considerably reduce radiation doses in the field of imaging in the next few years.</div></div><div><h3>Conclusion</h3><div>The reinforcement of continuous training and the introduction of training modules in the curriculum of Moroccan medical physicists’ as well as a broad awareness of the benefits of AI are guarantees for the successful implementation of this innovative technology.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 75-80"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioelectromagnetic fields as signaling currents of life 作为生命信号流的生物电磁场
Q1 Health Professions Pub Date : 2025-04-01 DOI: 10.1016/j.radmp.2024.09.001
Haiying Wang, Weijin Zou, Yi Cao
Bioelectromagnetic signaling, a fundamental aspect of biological systems, has gained increasing attention in recent years. This review synthesizes current knowledge and recent advancements in bioelectromagnetic research, covering principles, evidence, and emerging applications. We discuss the generation, reception, and roles of bioelectromagnetic fields in living organisms, focusing on intercellular and organism-level communication. The review also examines therapeutic applications, and technological innovations arising from our understanding of bioelectromagnetic phenomena. Finally, we outline future research directions that promise to deepen our comprehension of life's electromagnetic dimensions and potentially revolutionize medicine and technology.
生物电磁信号是生物系统的一个基本方面,近年来受到越来越多的关注。这篇综述综述了生物电磁研究的现有知识和最新进展,涵盖原理、证据和新兴应用。我们讨论了生物电磁场在生物体内的产生、接收和作用,重点关注细胞间和生物体层面的交流。这篇综述还探讨了治疗应用,以及我们对生物电磁现象的理解所带来的技术创新。最后,我们概述了未来的研究方向,这些方向有望加深我们对生命电磁层面的理解,并有可能给医学和技术带来革命性的变化。
{"title":"Bioelectromagnetic fields as signaling currents of life","authors":"Haiying Wang,&nbsp;Weijin Zou,&nbsp;Yi Cao","doi":"10.1016/j.radmp.2024.09.001","DOIUrl":"10.1016/j.radmp.2024.09.001","url":null,"abstract":"<div><div>Bioelectromagnetic signaling, a fundamental aspect of biological systems, has gained increasing attention in recent years. This review synthesizes current knowledge and recent advancements in bioelectromagnetic research, covering principles, evidence, and emerging applications. We discuss the generation, reception, and roles of bioelectromagnetic fields in living organisms, focusing on intercellular and organism-level communication. The review also examines therapeutic applications, and technological innovations arising from our understanding of bioelectromagnetic phenomena. Finally, we outline future research directions that promise to deepen our comprehension of life's electromagnetic dimensions and potentially revolutionize medicine and technology.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 112-118"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival benefits and toxicity effects of radiotherapy and immunotherapy treatments in melanoma patients with brain metastases: A meta-analysis
Q1 Health Professions Pub Date : 2025-04-01 DOI: 10.1016/j.radmp.2025.02.001
Jialing Wen , Xiangdi Meng , Wenchao Gu , Shenke Zhang , Li Sui , Gang Guo , Liang Yan , Wangcai Ren , Xuanzhang Tu , Kensuke Osada , Takashi Shimokawa , Yang Li , Liqiu Ma

Objective

To compare the efficacy and toxicity of four treatment strategies in patients with MBMs.

Methods

A systematic literature search of the Cochrane, PubMed, Embase, Web of Science, and OVID Medline databases was performed until July 24, 2024. A total of four therapeutic modalities for MBMs, including immune checkpoint inhibitor (ICI) monotherapy, radiotherapy (RT) alone, ICI combined with RT (ICI ​+ ​RT), and dual ICI therapy (ICI ​+ ​ICI), were evaluated by the overall survival (OS), intracranial progression-free survival (iPFS), and adverse effect (AE). The meta-analysis was performed using R language and registered in PROSPERO (registration no. CRD42023480912).

Results

This study included 33 studies comprising 2,496 patients with MBMs. ICI combined with RT and dual ICI therapy improved the 6 and 12-month OS rates compared with ICI monotherapy and RT alone. There was no significant difference in OS between the ICI + RT group and the ICI + ICI group. Similar results were observed for iPFS, with the combination treatment groups showing a significant difference compared with the treatment groups alone. However, no significant difference was observed in 1-year iPFS between the ICI + RT group and the ICI + ICI group (P ​= ​0.07), whereas the ICI + ICI group demonstrated superior 2-year iPFS compared with the ICI + RT group (P ​< 0.05). Furthermore, the survival advantages of combination therapy gradually decreased with increasing duration of treatment. Additionally, compared with ICI monotherapy, dual ICI therapy significantly increased the incidence of AEs over grade 3 (ICI ​+ ​ICI: 57% vs. ICI: 11%, P ​< ​0.0001), whereas ICI combined with RT did not significantly differ (ICI ​+ ​RT: 19% vs. ICI: 11%, P ​= ​0.14).

Conclusion

The combination of ICI with RT offers superior survival benefits without increasing toxicity in patients with MBMs. However, this survival benefit decreases over time, and further optimizing the treatment strategy is essential for improving the outcomes of patients with MBMs.
{"title":"Survival benefits and toxicity effects of radiotherapy and immunotherapy treatments in melanoma patients with brain metastases: A meta-analysis","authors":"Jialing Wen ,&nbsp;Xiangdi Meng ,&nbsp;Wenchao Gu ,&nbsp;Shenke Zhang ,&nbsp;Li Sui ,&nbsp;Gang Guo ,&nbsp;Liang Yan ,&nbsp;Wangcai Ren ,&nbsp;Xuanzhang Tu ,&nbsp;Kensuke Osada ,&nbsp;Takashi Shimokawa ,&nbsp;Yang Li ,&nbsp;Liqiu Ma","doi":"10.1016/j.radmp.2025.02.001","DOIUrl":"10.1016/j.radmp.2025.02.001","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the efficacy and toxicity of four treatment strategies in patients with MBMs.</div></div><div><h3>Methods</h3><div>A systematic literature search of the Cochrane, PubMed, Embase, Web of Science, and OVID Medline databases was performed until July 24, 2024. A total of four therapeutic modalities for MBMs, including immune checkpoint inhibitor (ICI) monotherapy, radiotherapy (RT) alone, ICI combined with RT (ICI ​+ ​RT), and dual ICI therapy (ICI ​+ ​ICI), were evaluated by the overall survival (OS), intracranial progression-free survival (iPFS), and adverse effect (AE). The meta-analysis was performed using R language and registered in PROSPERO (registration no. CRD42023480912).</div></div><div><h3>Results</h3><div>This study included 33 studies comprising 2,496 patients with MBMs. ICI combined with RT and dual ICI therapy improved the 6 and 12-month OS rates compared with ICI monotherapy and RT alone. There was no significant difference in OS between the ICI + RT group and the ICI + ICI group. Similar results were observed for iPFS, with the combination treatment groups showing a significant difference compared with the treatment groups alone. However, no significant difference was observed in 1-year iPFS between the ICI + RT group and the ICI + ICI group (<em>P</em> ​= ​0.07), whereas the ICI + ICI group demonstrated superior 2-year iPFS compared with the ICI + RT group (<em>P</em> ​&lt; 0.05). Furthermore, the survival advantages of combination therapy gradually decreased with increasing duration of treatment. Additionally, compared with ICI monotherapy, dual ICI therapy significantly increased the incidence of AEs over grade 3 (ICI ​+ ​ICI: 57% <em>vs.</em> ICI: 11%, <em>P</em> ​&lt; ​0.0001), whereas ICI combined with RT did not significantly differ (ICI ​+ ​RT: 19% <em>vs.</em> ICI: 11%, <em>P</em> ​= ​0.14).</div></div><div><h3>Conclusion</h3><div>The combination of ICI with RT offers superior survival benefits without increasing toxicity in patients with MBMs. However, this survival benefit decreases over time, and further optimizing the treatment strategy is essential for improving the outcomes of patients with MBMs.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 91-102"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupational radiation exposure analysis in industrial radiography in Bangladesh 孟加拉国工业放射学的职业辐照分析
Q1 Health Professions Pub Date : 2025-04-01 DOI: 10.1016/j.radmp.2025.03.002
Mehedi Hassan, Shahadat Hossain, M.M. Mahfuz Siraz, Shikha Pervin, Nazneen Sultana, Md Zakir Hossain, Selina Yeasmin

Objective

To evaluate the workload management and guarantee the technical concerns for an appropriate radiation protection method in non-destructive testing (NDT) industries in Bangladesh.

Methods

The radiation exposure for 721 workers was investigated in industrial radiography through Bangladesh during 2019–2022. A thermoluminescence dosimeter (TLD-100) was used to measure the occupational exposure with the operational dose quantity Hp(10). All the readout procedures were completed using the Harshaw TLD reader (model 4500).

Results

The collective effective dose was 75.73, 115.35, 150.18, and 96 ​mSv in year 2019, 2020, 2021, and 2022, respectively. The maximum effective dose received among the workers was 19.45, 3.8, 19.19, and 19.53 ​mSv, respectively, which remained within the stipulated dose limits imposed by Nuclear Safety and Radiation Control (NSRC) Rules-1997, Bangladesh and International Commission on Radiological Protection (ICRP-103). The mean annual individual dose was 0.53, 0.8, 0.83, and 0.39 ​mSv in 2019, 2020, 2021, and 2022, respectively. The mean value of excess life-time cancer risk (ELCR) was found 1.12 ​× ​10−3.

Conclusion

The industrial radiography facilities of Bangladesh may be certain that their current safety protocols are adequate. Additionally, few recommendations for safe industrial radiography practices have also been offered.
目标对孟加拉国无损检测(NDT)行业的工作量管理进行评估,并为适当的辐射防护方法提供技术保障。方法在2019-2022年期间,对孟加拉国工业放射摄影行业的721名工人进行了辐射暴露调查。使用热释光剂量计(TLD-100)测量职业辐照度,工作剂量量为 Hp(10)。结果 2019 年、2020 年、2021 年和 2022 年的总有效剂量分别为 75.73、115.35、150.18 和 96 mSv。工人受到的最大有效剂量分别为 19.45、3.8、19.19 和 19.53 mSv,均未超出孟加拉国核安全与辐射控制(NSRC)规则-1997 和国际辐射防护委员会(ICRP-103)规定的剂量限值。2019 年、2020 年、2021 年和 2022 年的个人年平均剂量分别为 0.53、0.8、0.83 和 0.39 毫希沃特。结论孟加拉国的工业射线照相设施可以确定其当前的安全协议是充分的。此外,还提出了一些关于工业射线照相安全操作的建议。
{"title":"Occupational radiation exposure analysis in industrial radiography in Bangladesh","authors":"Mehedi Hassan,&nbsp;Shahadat Hossain,&nbsp;M.M. Mahfuz Siraz,&nbsp;Shikha Pervin,&nbsp;Nazneen Sultana,&nbsp;Md Zakir Hossain,&nbsp;Selina Yeasmin","doi":"10.1016/j.radmp.2025.03.002","DOIUrl":"10.1016/j.radmp.2025.03.002","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the workload management and guarantee the technical concerns for an appropriate radiation protection method in non-destructive testing (NDT) industries in Bangladesh.</div></div><div><h3>Methods</h3><div>The radiation exposure for 721 workers was investigated in industrial radiography through Bangladesh during 2019–2022. A thermoluminescence dosimeter (TLD-100) was used to measure the occupational exposure with the operational dose quantity <em>H</em><sub>p</sub>(10). All the readout procedures were completed using the Harshaw TLD reader (model 4500).</div></div><div><h3>Results</h3><div>The collective effective dose was 75.73, 115.35, 150.18, and 96 ​mSv in year 2019, 2020, 2021, and 2022, respectively. The maximum effective dose received among the workers was 19.45, 3.8, 19.19, and 19.53 ​mSv, respectively, which remained within the stipulated dose limits imposed by Nuclear Safety and Radiation Control (NSRC) Rules-1997, Bangladesh and International Commission on Radiological Protection (ICRP-103). The mean annual individual dose was 0.53, 0.8, 0.83, and 0.39 ​mSv in 2019, 2020, 2021, and 2022, respectively. The mean value of excess life-time cancer risk (ELCR) was found 1.12 ​× ​10<sup>−3</sup>.</div></div><div><h3>Conclusion</h3><div>The industrial radiography facilities of Bangladesh may be certain that their current safety protocols are adequate. Additionally, few recommendations for safe industrial radiography practices have also been offered.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 107-111"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Swift prediction of personalized head and chest organ doses from CT examinations via neural networks with optimized quantity of hidden layers and radiomics features
Q1 Health Professions Pub Date : 2025-04-01 DOI: 10.1016/j.radmp.2025.02.002
Wencheng Shao , Xin Lin , Ying Huang , Liangyong Qu , Weihai Zhuo , Haikuan Liu

Objective

To utilize radiomics features to enhance the prediction of personalized organ doses from CT scans, in order to explore methods for improving neural network-based models.

Methods

Patient CT DICOM files were processed using DeepViewer to define regions of interest (ROIs) in their organs. Radiomics features were extracted from the CT images and ROIs, and benchmark organ doses were calculated using Monte Carlo simulations. Fully-connected neural networks (FCNN) were trained with radiomics features to predict organ doses. The FCNN model was optimized by adjusting the number of input radiomics features and FCNN layers. Performance was evaluated using relative root mean squared error (RRMSE) and R-squared (R2).

Results

Higher RRMSE and lower R2 values are observed when fewer than 30 input radiomics features are used for head CTs and fewer than 10 for chesst CTs. Increasing input features didn't significantly improve FCNN's performance. For head CTs, FCNN's layer quantities affected predictive stability, with better robustness observed with 4- and 5-layer FCNN. Specifically, the median RRMSE was reduced to 8.14% for the brain, 10.27% for the left eye, and 10.16% for the right eye when using 30 or more radiomics features. For chest CTs, the model's predictive stability was less sensitive to the number of layers, with median RRMSE values of 9.58% for the left lung and 9.44% for the right lung, and R² values of 0.76 for both lungs.

Conclusions

Optimizing feature quantities and neural network layers enhances performance in predicting organ doses from CT scans. Specifically, head CTs show optimal results with 4–5 layers, while chest CTs do not significantly benefit from increased layers.
{"title":"Swift prediction of personalized head and chest organ doses from CT examinations via neural networks with optimized quantity of hidden layers and radiomics features","authors":"Wencheng Shao ,&nbsp;Xin Lin ,&nbsp;Ying Huang ,&nbsp;Liangyong Qu ,&nbsp;Weihai Zhuo ,&nbsp;Haikuan Liu","doi":"10.1016/j.radmp.2025.02.002","DOIUrl":"10.1016/j.radmp.2025.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>To utilize radiomics features to enhance the prediction of personalized organ doses from CT scans, in order to explore methods for improving neural network-based models.</div></div><div><h3>Methods</h3><div>Patient CT DICOM files were processed using DeepViewer to define regions of interest (ROIs) in their organs. Radiomics features were extracted from the CT images and ROIs, and benchmark organ doses were calculated using Monte Carlo simulations. Fully-connected neural networks (FCNN) were trained with radiomics features to predict organ doses. The FCNN model was optimized by adjusting the number of input radiomics features and FCNN layers. Performance was evaluated using relative root mean squared error (<em>RRMSE</em>) and <em>R</em>-squared (<em>R</em><sup>2</sup>).</div></div><div><h3>Results</h3><div>Higher RRMSE and lower <em>R</em><sup>2</sup> values are observed when fewer than 30 input radiomics features are used for head CTs and fewer than 10 for chesst CTs. Increasing input features didn't significantly improve FCNN's performance. For head CTs, FCNN's layer quantities affected predictive stability, with better robustness observed with 4- and 5-layer FCNN. Specifically, the median RRMSE was reduced to 8.14% for the brain, 10.27% for the left eye, and 10.16% for the right eye when using 30 or more radiomics features. For chest CTs, the model's predictive stability was less sensitive to the number of layers, with median RRMSE values of 9.58% for the left lung and 9.44% for the right lung, and <em>R</em>² values of 0.76 for both lungs.</div></div><div><h3>Conclusions</h3><div>Optimizing feature quantities and neural network layers enhances performance in predicting organ doses from CT scans. Specifically, head CTs show optimal results with 4–5 layers, while chest CTs do not significantly benefit from increased layers.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 2","pages":"Pages 81-90"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence for chest X-ray image enhancement
Q1 Health Professions Pub Date : 2025-02-01 DOI: 10.1016/j.radmp.2024.12.003
Liming Song , Hongfei Sun , Haonan Xiao , Sai Kit Lam , Yuefu Zhan , Ge Ren , Jing Cai
The chest X-ray (CXR) imaging has been the most frequently performed radiographic examination for decades, and its demand continues to grow due to their critical role in diagnosing various diseases. However, the image quality of CXR has long been a factor limiting their diagnostic accuracy. As a post-processing procedure, image enhancement can cost-effectively improve image quality. Recently, the successful application of deep learning (DL) algorithms in medical image analysis has prompted researchers to propose and design DL-based CXR image enhancement algorithms. This review examines advancements in CXR image enhancement methods from 2018 to 2023, categorizing them into four groups: bone suppression, image denoising, super-resolution reconstruction, and contrast enhancement. For each group, the unique approaches, strengths, and challenges are analyzed. The review concludes by discussing shared challenges across these methods and proposing directions for future research.
{"title":"Artificial intelligence for chest X-ray image enhancement","authors":"Liming Song ,&nbsp;Hongfei Sun ,&nbsp;Haonan Xiao ,&nbsp;Sai Kit Lam ,&nbsp;Yuefu Zhan ,&nbsp;Ge Ren ,&nbsp;Jing Cai","doi":"10.1016/j.radmp.2024.12.003","DOIUrl":"10.1016/j.radmp.2024.12.003","url":null,"abstract":"<div><div>The chest X-ray (CXR) imaging has been the most frequently performed radiographic examination for decades, and its demand continues to grow due to their critical role in diagnosing various diseases. However, the image quality of CXR has long been a factor limiting their diagnostic accuracy. As a post-processing procedure, image enhancement can cost-effectively improve image quality. Recently, the successful application of deep learning (DL) algorithms in medical image analysis has prompted researchers to propose and design DL-based CXR image enhancement algorithms. This review examines advancements in CXR image enhancement methods from 2018 to 2023, categorizing them into four groups: bone suppression, image denoising, super-resolution reconstruction, and contrast enhancement. For each group, the unique approaches, strengths, and challenges are analyzed. The review concludes by discussing shared challenges across these methods and proposing directions for future research.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 1","pages":"Pages 61-68"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased dicentric chromosome in peripheral lymphocytes is related to acute skin toxicity induced by radiotherapy in cancer patients
Q1 Health Professions Pub Date : 2025-02-01 DOI: 10.1016/j.radmp.2024.07.003
Minjie Li , Yu Gao , Lin Han , Ping Wang , Jie Li , Junhua Song , Shasha Du , Yunfei Zhang , Yumin Lyu

Objective

To investigate the impacts of radiotherapy (RT) on dicentric chromosomes in peripheral blood lymphocytes of cancer patients, in order to explore the relationship between dicentric chromosomes and RT-induced adverse reactions.

Methods

A total of 33 cancer patients after postoperative RT in a tertiary hospital from October 2021 to May 2022 were enrolled in this study. These patients were grouped according to the grade of acute skin and marrow toxicities determined based on the scoring criteria for acute morbidity developed by the Radiation Therapy Oncology Group (RTOG). Peripheral blood samples were collected from each patient before and after RT, followed by whole-blood lymphocyte culture and chromosome analysis. Dicentric chromosomes were searched automatically using a high-throughput chromosome analysis system and were then confirmed manually. Finally, the relationships of the frequency of dicentric chromosomes (also referred to as the dic frequency) with acute skin and marrow toxicities were assessed.

Results

After RT, the mean counts of white blood cells (WBCs), lymphocytes, and platelets significantly decreased, while the red blood cells (RBCs) and hemoglobin notably increased (P ​< ​0.001), while the dic frequency was elevated remarkably, significantly higher in patients with higher-grade (>1) acute skin toxicities compared to those with lower-grade (=1) acute skin toxicities (Z ​= ​−1.985, P ​= ​0.047). However, no significant relationship was observed between the dic frequency and acute marrow toxicity after RT (P ​> ​0.05). Logistic regression showed that radiosensitivity denoted by the post-RT dic frequency in peripheral blood lymphocytes produced insignificant impacts on the severity of RT-induced acute skin toxicities (P ​= ​0.060).

Conclusion

The elevated dic frequency in peripheral blood lymphocytes of cancer patients with higher-grade acute skin toxicities suggests enhanced radiosensitivity of peripheral blood lymphocytes, which is associated with the occurrence of RT-induced adverse reactions.
{"title":"Increased dicentric chromosome in peripheral lymphocytes is related to acute skin toxicity induced by radiotherapy in cancer patients","authors":"Minjie Li ,&nbsp;Yu Gao ,&nbsp;Lin Han ,&nbsp;Ping Wang ,&nbsp;Jie Li ,&nbsp;Junhua Song ,&nbsp;Shasha Du ,&nbsp;Yunfei Zhang ,&nbsp;Yumin Lyu","doi":"10.1016/j.radmp.2024.07.003","DOIUrl":"10.1016/j.radmp.2024.07.003","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the impacts of radiotherapy (RT) on dicentric chromosomes in peripheral blood lymphocytes of cancer patients, in order to explore the relationship between dicentric chromosomes and RT-induced adverse reactions.</div></div><div><h3>Methods</h3><div>A total of 33 cancer patients after postoperative RT in a tertiary hospital from October 2021 to May 2022 were enrolled in this study. These patients were grouped according to the grade of acute skin and marrow toxicities determined based on the scoring criteria for acute morbidity developed by the Radiation Therapy Oncology Group (RTOG). Peripheral blood samples were collected from each patient before and after RT, followed by whole-blood lymphocyte culture and chromosome analysis. Dicentric chromosomes were searched automatically using a high-throughput chromosome analysis system and were then confirmed manually. Finally, the relationships of the frequency of dicentric chromosomes (also referred to as the dic frequency) with acute skin and marrow toxicities were assessed.</div></div><div><h3>Results</h3><div>After RT, the mean counts of white blood cells (WBCs), lymphocytes, and platelets significantly decreased, while the red blood cells (RBCs) and hemoglobin notably increased (<em>P</em> ​&lt; ​0.001), while the dic frequency was elevated remarkably, significantly higher in patients with higher-grade (&gt;1) acute skin toxicities compared to those with lower-grade (=1) acute skin toxicities (<em>Z</em> ​= ​−1.985, <em>P</em> ​= ​0.047). However, no significant relationship was observed between the dic frequency and acute marrow toxicity after RT (<em>P</em> ​&gt; ​0.05). Logistic regression showed that radiosensitivity denoted by the post-RT dic frequency in peripheral blood lymphocytes produced insignificant impacts on the severity of RT-induced acute skin toxicities (<em>P</em> ​= ​0.060).</div></div><div><h3>Conclusion</h3><div>The elevated dic frequency in peripheral blood lymphocytes of cancer patients with higher-grade acute skin toxicities suggests enhanced radiosensitivity of peripheral blood lymphocytes, which is associated with the occurrence of RT-induced adverse reactions.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 1","pages":"Pages 22-27"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the detection efficiencies of liquid 99Tcm, 131I, and 18F in a well-type NaI(Tl) gamma spectrometer
Q1 Health Professions Pub Date : 2025-02-01 DOI: 10.1016/j.radmp.2024.12.001
Jiayu Liu, Xiaojun Lu, Chao Zhao

Objective

To assess the detection efficiencies of liquid radioisotopes in a well-type NaI(Tl) gamma spectrometer, focusing on the short-lived isotopes 99Tcm, 131I, and 18F.

Methods

The detection efficiencies of liquid 99Tcm, 131I, and 18F in a well-type NaI(Tl) gamma spectrometer were systematically investigated through calibration experiments and Monte Carlo simulations, and accounting for the coincidence-summing effect.

Results

The results indicated that the detection efficiencies of 99Tcm, 131I, and 18F varied from 64.4% to 72.3%, 34.8%–43.1% and 27.3%–28.5% for different sample volumes ranging from 15 ​mL to 80 ​mL, respectively. The simulated detection efficiencies were highly consistent with the experimental results, with a largest relative deviation of 5% for the 3 radionuclides and 4 different sample volumes.

Conclusion

The consistent results between the calibration experiments and Monte Carlo simulations reveal that this measuring device possesses high detection efficiencies of 99Tcm, 131I, and 18F, making it suitable for measuring low-level activity radioactive liquids, such as radioactive waste liquids to be discharged.
{"title":"Study on the detection efficiencies of liquid 99Tcm, 131I, and 18F in a well-type NaI(Tl) gamma spectrometer","authors":"Jiayu Liu,&nbsp;Xiaojun Lu,&nbsp;Chao Zhao","doi":"10.1016/j.radmp.2024.12.001","DOIUrl":"10.1016/j.radmp.2024.12.001","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the detection efficiencies of liquid radioisotopes in a well-type NaI(Tl) gamma spectrometer, focusing on the short-lived isotopes <sup>99</sup>Tc<sup>m</sup>, <sup>131</sup>I, and <sup>18</sup>F.</div></div><div><h3>Methods</h3><div>The detection efficiencies of liquid <sup>99</sup>Tc<sup>m</sup>, <sup>131</sup>I, and <sup>18</sup>F in a well-type NaI(Tl) gamma spectrometer were systematically investigated through calibration experiments and Monte Carlo simulations, and accounting for the coincidence-summing effect.</div></div><div><h3>Results</h3><div>The results indicated that the detection efficiencies of <sup>99</sup>Tc<sup>m</sup>, <sup>131</sup>I, and <sup>18</sup>F varied from 64.4% to 72.3%, 34.8%–43.1% and 27.3%–28.5% for different sample volumes ranging from 15 ​mL to 80 ​mL, respectively. The simulated detection efficiencies were highly consistent with the experimental results, with a largest relative deviation of 5% for the 3 radionuclides and 4 different sample volumes.</div></div><div><h3>Conclusion</h3><div>The consistent results between the calibration experiments and Monte Carlo simulations reveal that this measuring device possesses high detection efficiencies of <sup>99</sup>Tc<sup>m</sup>, <sup>131</sup>I, and <sup>18</sup>F, making it suitable for measuring low-level activity radioactive liquids, such as radioactive waste liquids to be discharged.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 1","pages":"Pages 46-50"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Radiation Medicine and Protection
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