安得拉邦维贾亚瓦达登革热病毒血清变异型的流行情况

P. Sowmya, D. Sarada, B. S. Babu, L. Krishnamraju
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引用次数: 0

摘要

被称为 DENV 1-4 的四种不同的登革热病毒株在感染人后可引起登革热。当多种血清型同时存在时,罹患登革出血热-登革休克综合征的风险就会增加。对登革热疑似病例的急性期血清进行了登革热病毒血清型检测。共对 169 份血清样本进行了 NS1 抗原检测,并对阳性样本进行了血清型鉴定。其中,41 份样本(24.2%)的 NS1 抗原呈阳性,通过常规 PCR 进行的 DENV 血清型分析显示,36.5% 的样本具有 DENV 血清型。所有血清型都是共同流行的,其中 DENV 1 血清型占 60%,其次是 DENV 2 血清型,分别占 20%。在 15 个病毒阳性样本中,9 个样本(60%)发现 DENV 1 单感染,3 个样本(20%)发现 DENV 2 单感染,1 个样本(6.6%)发现 DENV 3+DENV 4 双感染,1 个样本(6.6%)发现 DENV 1 + DENV 4 双感染,1 个样本(6.6%)发现 DENV 1 + DENV 3 + DENV 4 三感染。这项研究提供了有关维贾亚瓦达登革热血清型分布的更多信息。感染登革热病毒的血清型和不同血清型的共循环对感染病毒者的疾病严重程度起着重要作用。
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PREVALENCE OF SEROTYPE VARIANTS OF DENGUE VIRUS IN VIJAYAWADA, ANDHRA PRADESH
The four different dengue virus strains known as DENV 1-4 can cause dengue fever when they infect a person. Risk of suffering dengue hemorrhagic fever-dengue shock syndrome increases when there is co-circulation of multiple serotypes. Acute phase sera from suspected cases of fever were tested for the presence of DENV serotypes. A total of 169 serum samples were tested for the presence of NS1 antigen and positive samples were subjected to Serotyping. Of these, 41 (24.2%) were positive for NS1 antigen and DENV Serotyping by Conventional PCR showed 36.5% had DENV serotypes. All the serotypes were found Co-circulating with DENV 1 60%, followed by DENV 2 serotype with 20% respectively. Among 15 virus positive samples, single infection with DENV 1 was found in 9(60%) samples, DENV 2 in 3(20%) samples, doubly infected with (DENV 3+DENV 4)in 1(6.6%) and (DENV 1 + DENV 4) in 1(6.6%) sample and triple infection with (DENV 1 + DENV 3 + DENV 4) was noticed in 1(6.6%) sample. This study provided more information on the dengue serotype distribution in Vijayawada. Infecting dengue serotype and Co-circulation of different serotypes play an important role in disease severity among individuals infected with the virus.
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