釉质基质蛋白衍生物(EMD)作为异种牙移植的辅助手段与单独使用异种牙移植治疗慢性牙周炎患者牙槽骨内缺损的效果比较:系统综述。

Aishwarya Babasaheb Kotkar, Amit Benjamin, Sangeeta Muglikar, Sneha Jethwani, Dhruti Shah
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摘要

背景:釉质基质衍生物(EMD)已被广泛应用于牙周再生治疗,而异种生物材料显示出良好的生物相容性和去矿化牛骨基质的骨传导性。因此,为了评估在慢性牙周炎患者的牙槽骨内缺损中使用伊奈梅尔基质蛋白衍生物作为牛源性异种移植的辅助治疗对临床疗效的改善情况:本系统综述考虑了针对 25-70 岁牙周炎患者的随机对照试验。在 PubMed、Google Scholar 和 EMBASE 数据库中进行了电子检索。选择了关于在牙周炎治疗中使用釉质基质衍生物(EMD)和异种移植体组合与单独使用异种移植体组合的研究。结果:经过两名审稿人的筛选,4 项研究被纳入定量分析。随机对照试验表明,应用釉质基质衍生物(EMD)和Xenograft与单独应用异种牙移植相比,牙周袋的缩小和临床附着水平的提高显著。结论:在慢性牙周炎患者的牙槽骨内缺损中,使用釉质基质衍生物(EMD)作为Xenograft的辅助治疗,与单独使用Xenograft相比,效果显著。
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EFFECT OF ENAMEL MATRIX PROTEIN DERIVATIVE (EMD) AS AN ADJUNCT TO XENOGRAFT COMPARED TO XENOGRAFT ALONE IN THE TREATMENT OF INTRABONY DEFECTS IN SUBJECTS WITH CHRONIC PERIODONTITIS: A SYSTEMATIC REVIEW.
Background: Enamel matrix derivative (EMD) has been widely used in periodontal regenerative treatment and the xenograft biomaterials show good biocompatibility and osteoconductivity of demineralized bovine bone matrix. So, to evaluate the improvement in clinical outcomes when Enamel Matrix Protein Derivative is used as an adjunct to Bovine-Derived Xenograft in intrabony defects of chronic periodontitis patients. Material And Methodology: In this systematic review, randomized controlled trials in subjects with periodontitis in the age group of 25-70 years were considered. An electronic search was made in PubMed, Google Scholar, and EMBASE databases. Studies concerning the use of a combination of enamel matrix derivative (EMD) and Xenograft compared with xenografts alone in periodontitis treatment were selected. Result: 4 studies were included in quantitative analysis after screening by two reviewers. Randomized controlled trials have indicated a signicantly higher pocket reduction and clinical attachment level gain after the application of enamel matrix derivative (EMD) and Xenograft compared with xenografts alone. Conclusion: The use of enamel matrix derivative (EMD) as an adjunct to Xenograft provides signicant results as compared to xenograft alone in intrabony defects of chronic periodontitis patients.
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