Spindle cell variant of ameloblastic carcinoma of mandible

Ameloblastic carcinoma (AC) is an aggressive odontogenic tumor. Spindle cell variant of AC (SCAC) is a rare entity and only sixteen cases of SCACs have been reported in the literature till date. We reported a case of 42-years-old male presented with swelling in right lower posterior region for 3 years. Radiology revealed multilocular osteolytic with cortical thinning and rarefaction showing internal non-enhancing areas. Histologically, the tumor revealed areas characteristic of ameloblastoma along with hypercellular areas of monomorphic spindle shaped cells merging into the stroma displaying cytological atypia, suggestive of AC with spindle cell variant. The purpose of this case report is to document an unusual case of spindle cell variant of AC, which can mimic other oral spindle cell lesions. Additionally, proliferative marker along with histological parameters like cytological atypia, mitoses and cell morphology is emphasized.