Ras相关蛋白Rab24是肝细胞癌预后的预测因子并促进肿瘤生长

IF 2.9 4区 医学 Q1 Medicine Journal of biomedical nanotechnology Pub Date : 2024-05-01 DOI:10.1166/jbn.2024.3831
Han Ding, Song Liu, Zhi-Guo Ding, Zhaojun Wang, Xingsheng Lu
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引用次数: 0

摘要

Ras相关蛋白Rab24是小GTP酶家族的成员,在调节细胞内蛋白质贩运方面发挥着重要作用。最近的研究发现了肝细胞癌(HCC)中 Rab24 的失调,但其临床意义和肿瘤相关效应还需要进一步研究。我们旨在研究 Rab24 的表达模式及其在 HCC 进展中的作用。我们从转录、mRNA 和蛋白水平分析了 Rab24 在 HCC 和邻近组织中的表达。通过单变量和多变量分析以及 Kaplan-Meier 生存分析评估了 Rab24 在 HCC 中的预后意义。通过细胞和异种移植实验研究了 Rab24 对细胞增殖的影响。我们的研究结果表明,与邻近肝脏组织相比,Rab24 在 HCC 组织中的表达量升高。Rab24 的高表达与肿瘤体积增大和肿瘤晚期相关。此外,Rab24高表达的HCC患者总生存率较低,Rab24被认为是一个独立的预后因素。操纵 Rab24 在 HCC 细胞系中的表达证明了它在促进肿瘤增殖方面的作用。抑制Rab24可明显减少异种移植在体内的生长。这项研究强调了Rab24高表达与较差的HCC预后之间的重要关联,表明Rab24有可能成为一种新的临床生物标记物和治疗靶点。
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Ras-Related Protein Rab24 is a Predictor for Hepatocellular Carcinoma Prognosis and Promotes Tumor Growth
Ras-related protein Rab24, a member of the small GTPase family, plays a vital role in regulating intracellular protein trafficking. Recent research has uncovered dysregulation of Rab24 in hepatocellular carcinoma (HCC), but its clinical implications and tumor-related effects require further investigation. We aimed to investigate Rab24’s expression patterns and its role in HCC progression. We analyzed Rab24 expression in HCC and adjacent tissues at the transcriptional, mRNA, and protein levels. The prognostic significance of Rab24 in HCC was assessed through univariate and multivariate analyses, along with Kaplan–Meier survival analysis. Rab24’s impact on cell proliferation was investigated through cellular and xenograft experiments. Our findings revealed elevated Rab24 expression in HCC tissues compared to adjacent liver tissues. High Rab24 expression correlated with larger tumor size and advanced tumor stage. Additionally, HCC patients with high Rab24 expression experienced poorer overall survival, with Rab24 identified as an independent prognostic factor. Manipulating Rab24 expression in HCC cell lines demonstrated its role in promoting tumor proliferation. Silencing Rab24 significantly reduced xenograft growth in vivo. This study highlights the significant association between high Rab24 expression and poorer HCC prognosis, suggesting Rab24’s potential as a novel clinical biomarker and therapeutic target.
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来源期刊
CiteScore
4.30
自引率
17.20%
发文量
145
审稿时长
2.3 months
期刊介绍: Information not localized
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