解读相互作用：华法林与甲硝唑的药物相互作用动力学

International journal of scientific research Pub Date : 2024-05-01 DOI:10.36106/ijsr/4703389

P. C. Sandhya, M Bhavana Reddy, V. Padma, S.V. Sathyapriya, Sujana Reddy, I. M, Sharath Chandra Reddy Turpu, V. Veera Vignesh

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引用次数: 0

摘要

本院收治了一名 65 岁的男性患者，主诉为用力时呼吸困难、吐血、恶心。患者 10 天前曾有便溏病史，并服用甲硝唑 400 毫克，一天两次，共服用 5 天。全身检查显示患者面色苍白，实验室检查显示 PT（测试）超过 100，外周血涂片显示正常红细胞、正常色素性红细胞、小红细胞和大红细胞混杂在一起，并伴有异型红细胞增多症，偶尔可见泪滴细胞。患者正在服用阿西曲马 2 毫克 0-0-2 片。停止服用阿昔洛韦，并为患者输注维生素 K、新鲜冰冻血浆和包装红细胞。患者的血红蛋白开始改善，PT 也在正常范围内。患者症状有所改善

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Unraveling the Interplay: Warfarin and Metronidazole Drug Interaction Dynamics

A 65 year old male patient was admitted in our hospital with complaints of breathlessness on exertion, haematemesis, history of malaena. Patient had history of loose stools 10 days back and was on tab metronidazole 400mg tid for 5 days. On general examination, there was pallor and laboratory investigations showed PT ( test ) more than 100, peripheral smear showed normocytic normochromic RBCs admixed with microcytic and macrocytic RBCs with anisopoikilocytosis showing occasional tear drop cells. Patient was on Tab Acitrom 2mg 0-0-2. Tab acitrom was stopped and patient was given Vit K, Fresh frozen plasma and Packed red blood cells transfusion. Patient's Haemoglobin started improving and PT came within normal limits. Patient improved symptomatically

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International journal of scientific research

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