Jianyong Feng, Qian Lin, Wenjie Wang, Chenjie Meng, Ruilin Du
{"title":"通过电纺丝基底和原位聚合制备高导电多尺度纤维工程生物医学贴片","authors":"Jianyong Feng, Qian Lin, Wenjie Wang, Chenjie Meng, Ruilin Du","doi":"10.1007/s12034-024-03155-x","DOIUrl":null,"url":null,"abstract":"<div><p>Myocardial infarction (MI) is one of the major diseases that threaten human life and health. The construction of cardiac patch by tissue engineering method and biomaterials is a promising way to treat MI clinically by improving electromechanical signal transduction in MI area. A highly conductive electrospun fibre-engineered biomedical patch with porous structure, mechanical support and conductive property was prepared by poly(lactic-co-glycolic acid) (PLGA), polyaniline (PANI), graphene oxide (GO) and multi-walled carbon nanotubes (MWCNT). PLGA, PLGA/MWCNT, PLGA/GO electrospinning fibre membrane substrates were prepared first and then <i>in-situ</i> polymerization of aniline (ANI) to form PANI/PLGA and PANI/PLGA/MWCNT fibre conductive patches. PLGA-blended fibre patch had a smooth fibre surface and an uniform fibre diameter, porous structure, fibre parallel arrangement, in which PLGA/MWCNT had larger ultimate strength and Young’s modulus. When the ANI concentration was 0.4 mol l<sup>−1</sup>, electrical conductivity reached the maximum value, and the electrical conductivity of PANI/PLGA fibre patch was significantly larger than that of PANI/PLGA/MWCNT fibre patch as the ANI concentration increased, which were 1.56 × 10<sup>−2</sup> and 6.06 × 10<sup>−3</sup> S cm<sup>−1</sup>, respectively. Highly conductive fibre membrane-engineered biomedical patch had excellent electrical and thermal stability, and improved signal transduction, with porous structure and mechanical support for potential MI repair.</p></div>","PeriodicalId":502,"journal":{"name":"Bulletin of Materials Science","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Highly conductive multiscale fibre-engineered biomedical patch prepared by electrospinning substrate and in-situ polymerization\",\"authors\":\"Jianyong Feng, Qian Lin, Wenjie Wang, Chenjie Meng, Ruilin Du\",\"doi\":\"10.1007/s12034-024-03155-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Myocardial infarction (MI) is one of the major diseases that threaten human life and health. The construction of cardiac patch by tissue engineering method and biomaterials is a promising way to treat MI clinically by improving electromechanical signal transduction in MI area. A highly conductive electrospun fibre-engineered biomedical patch with porous structure, mechanical support and conductive property was prepared by poly(lactic-co-glycolic acid) (PLGA), polyaniline (PANI), graphene oxide (GO) and multi-walled carbon nanotubes (MWCNT). PLGA, PLGA/MWCNT, PLGA/GO electrospinning fibre membrane substrates were prepared first and then <i>in-situ</i> polymerization of aniline (ANI) to form PANI/PLGA and PANI/PLGA/MWCNT fibre conductive patches. PLGA-blended fibre patch had a smooth fibre surface and an uniform fibre diameter, porous structure, fibre parallel arrangement, in which PLGA/MWCNT had larger ultimate strength and Young’s modulus. When the ANI concentration was 0.4 mol l<sup>−1</sup>, electrical conductivity reached the maximum value, and the electrical conductivity of PANI/PLGA fibre patch was significantly larger than that of PANI/PLGA/MWCNT fibre patch as the ANI concentration increased, which were 1.56 × 10<sup>−2</sup> and 6.06 × 10<sup>−3</sup> S cm<sup>−1</sup>, respectively. Highly conductive fibre membrane-engineered biomedical patch had excellent electrical and thermal stability, and improved signal transduction, with porous structure and mechanical support for potential MI repair.</p></div>\",\"PeriodicalId\":502,\"journal\":{\"name\":\"Bulletin of Materials Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-05-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of Materials Science\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12034-024-03155-x\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Materials Science","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s12034-024-03155-x","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Highly conductive multiscale fibre-engineered biomedical patch prepared by electrospinning substrate and in-situ polymerization
Myocardial infarction (MI) is one of the major diseases that threaten human life and health. The construction of cardiac patch by tissue engineering method and biomaterials is a promising way to treat MI clinically by improving electromechanical signal transduction in MI area. A highly conductive electrospun fibre-engineered biomedical patch with porous structure, mechanical support and conductive property was prepared by poly(lactic-co-glycolic acid) (PLGA), polyaniline (PANI), graphene oxide (GO) and multi-walled carbon nanotubes (MWCNT). PLGA, PLGA/MWCNT, PLGA/GO electrospinning fibre membrane substrates were prepared first and then in-situ polymerization of aniline (ANI) to form PANI/PLGA and PANI/PLGA/MWCNT fibre conductive patches. PLGA-blended fibre patch had a smooth fibre surface and an uniform fibre diameter, porous structure, fibre parallel arrangement, in which PLGA/MWCNT had larger ultimate strength and Young’s modulus. When the ANI concentration was 0.4 mol l−1, electrical conductivity reached the maximum value, and the electrical conductivity of PANI/PLGA fibre patch was significantly larger than that of PANI/PLGA/MWCNT fibre patch as the ANI concentration increased, which were 1.56 × 10−2 and 6.06 × 10−3 S cm−1, respectively. Highly conductive fibre membrane-engineered biomedical patch had excellent electrical and thermal stability, and improved signal transduction, with porous structure and mechanical support for potential MI repair.
期刊介绍:
The Bulletin of Materials Science is a bi-monthly journal being published by the Indian Academy of Sciences in collaboration with the Materials Research Society of India and the Indian National Science Academy. The journal publishes original research articles, review articles and rapid communications in all areas of materials science. The journal also publishes from time to time important Conference Symposia/ Proceedings which are of interest to materials scientists. It has an International Advisory Editorial Board and an Editorial Committee. The Bulletin accords high importance to the quality of articles published and to keep at a minimum the processing time of papers submitted for publication.