Chen-xi Wang , Chen-yue Li , Meng-kun Yan , Wen-qiong Wang , Li-jiang Xuan
{"title":"何首乌中五种未被描述的 drimane 型倍半萜类化合物","authors":"Chen-xi Wang , Chen-yue Li , Meng-kun Yan , Wen-qiong Wang , Li-jiang Xuan","doi":"10.1016/j.phytol.2024.05.007","DOIUrl":null,"url":null,"abstract":"<div><p>In order to find various structural and active compounds, 95 % ethanol extract of <em>P. hydropiper</em> was investigated to obtain five undescribed drimane sesquiterpenes 3-O-angeloyl-11-O-methyldanilol (<strong>1</strong>), 3-O-tigloyl-11-O-methyldanilol (<strong>2</strong>), 3-O-(3′-methylbutenoyl)-11-O-methyldanilol (<strong>3</strong>), 3-O-(2′-metylbutanoyl)-11-O-methyldanilol (<strong>4</strong>) and 2α, 3β-ditigloyloxy-11-O-methylisodrimeninol (<strong>5</strong>). Their structures were established by extensive spectroscopic analyses. Furthermore, 3-O-angeloyl-11-O-methyldanilol (<strong>1</strong>) showed moderate anti-platelet aggregation activity according to in <em>vitro</em> pharmacological evaluation.</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"61 ","pages":"Pages 236-241"},"PeriodicalIF":1.3000,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Five undescribed drimane-type sesquiterpenes from Polygonum hydropiper\",\"authors\":\"Chen-xi Wang , Chen-yue Li , Meng-kun Yan , Wen-qiong Wang , Li-jiang Xuan\",\"doi\":\"10.1016/j.phytol.2024.05.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In order to find various structural and active compounds, 95 % ethanol extract of <em>P. hydropiper</em> was investigated to obtain five undescribed drimane sesquiterpenes 3-O-angeloyl-11-O-methyldanilol (<strong>1</strong>), 3-O-tigloyl-11-O-methyldanilol (<strong>2</strong>), 3-O-(3′-methylbutenoyl)-11-O-methyldanilol (<strong>3</strong>), 3-O-(2′-metylbutanoyl)-11-O-methyldanilol (<strong>4</strong>) and 2α, 3β-ditigloyloxy-11-O-methylisodrimeninol (<strong>5</strong>). Their structures were established by extensive spectroscopic analyses. Furthermore, 3-O-angeloyl-11-O-methyldanilol (<strong>1</strong>) showed moderate anti-platelet aggregation activity according to in <em>vitro</em> pharmacological evaluation.</p></div>\",\"PeriodicalId\":20408,\"journal\":{\"name\":\"Phytochemistry Letters\",\"volume\":\"61 \",\"pages\":\"Pages 236-241\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-05-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S187439002400079X\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S187439002400079X","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Five undescribed drimane-type sesquiterpenes from Polygonum hydropiper
In order to find various structural and active compounds, 95 % ethanol extract of P. hydropiper was investigated to obtain five undescribed drimane sesquiterpenes 3-O-angeloyl-11-O-methyldanilol (1), 3-O-tigloyl-11-O-methyldanilol (2), 3-O-(3′-methylbutenoyl)-11-O-methyldanilol (3), 3-O-(2′-metylbutanoyl)-11-O-methyldanilol (4) and 2α, 3β-ditigloyloxy-11-O-methylisodrimeninol (5). Their structures were established by extensive spectroscopic analyses. Furthermore, 3-O-angeloyl-11-O-methyldanilol (1) showed moderate anti-platelet aggregation activity according to in vitro pharmacological evaluation.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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