磷脂酰肌醇 3,4-二磷酸：走出阴影，成为焦点

IF 6 2区生物学 Q1 CELL BIOLOGY Current Opinion in Cell Biology Pub Date : 2024-05-21 DOI:10.1016/j.ceb.2024.102372

Jayatee Ray , David G. Sapp , Gregory D. Fairn

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引用次数: 0

摘要

磷脂酰肌醇 3- 激酶调节许多细胞功能，包括迁移、生长、增殖和细胞存活。早期的研究将抑制 I 类 PI3K 与磷脂酰肌醇 3,4,5-三磷酸酯（PIP3）的损失等同起来，但随着时间的推移，人们意识到这些治疗也会消耗磷脂酰肌醇 3,4-二磷酸酯（PI(3,4)P2）。近年来，由于使用了更好的工具，对其新陈代谢有了更深入的了解，人们得以确定 PI(3,4)P2 的具体作用。这包括 PI（3,4）P2 的产生及其效应物 Akt2 在生长因子信号传导下的激活。相反，溶酶体中的 PI(3,4)P2 在生长因子缺乏时是 mTORC1 的负调控因子。越来越多的文献也证明，PI(3,4)P2 控制着许多动态的质膜过程。PI(3,4)P2 在细胞生物学中的重要性日益明显。

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Phosphatidylinositol 3,4-bisphosphate: Out of the shadows and into the spotlight

Phosphoinositide 3-kinases regulate many cellular functions, including migration, growth, proliferation, and cell survival. Early studies equated the inhibition of Class I PI3Ks with loss of; phosphatidylinositol 3,4,5-trisphosphate (PIP3), but over time, it was realised that these; treatments also depleted phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). In recent years, the; use of better tools and an improved understanding of its metabolism have allowed for the; identification of specific roles of PI(3,4)P2. This includes the production of PI(3,4)P2 and the; activation of its effector Akt2 in response to growth factor signalling. In contrast, a lysosomal pool of PI(3,4)P2 is a negative regulator of mTORC1 during growth factor deprivation. A growing body of literature also demonstrates that PI(3,4)P2 controls many dynamic plasmalemmal processes. The significance of PI(3,4)P₂ in cell biology is increasingly evident.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.