先驱因素:天性还是后天培养?

IF 6.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2024-06-01 Epub Date: 2024-05-22 DOI:10.1080/10409238.2024.2355885
Shane Stoeber, Holly Godin, Cheng Xu, Lu Bai
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引用次数: 0

摘要

染色质中核糖体密集,这限制了许多染色质相关蛋白的可及性。先驱因子(PFs)通常被视为一组特殊的序列特异性转录因子(TFs),它们能识别核糖体嵌入的基序,侵入紧密的染色质并产生开放的染色质区域。通过这一过程,PFs 启动了一系列在基因调控和细胞分化中发挥关键作用的事件。该领域目前存在的一个争论是,PFs 是否属于具有内在 "先驱活性 "的独特 TFs 子集,或者是否所有 TFs 都有可能在特定细胞环境中发挥 PFs 的功能。对于定义先锋活性的关键特征也存在不同观点。在这篇综述中,我们将介绍与这些不同观点相关的文献证据,并讨论如何调和这些观点。核糖体紧密结合和结构相容性等内在特性和细胞条件(如浓度和辅助因子的可用性)可能对 PF 的功能都很重要。
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Pioneer factors: nature or nurture?

Chromatin is densely packed with nucleosomes, which limits the accessibility of many chromatin-associated proteins. Pioneer factors (PFs) are usually viewed as a special group of sequence-specific transcription factors (TFs) that can recognize nucleosome-embedded motifs, invade compact chromatin, and generate open chromatin regions. Through this process, PFs initiate a cascade of events that play key roles in gene regulation and cell differentiation. A current debate in the field is if PFs belong to a unique subset of TFs with intrinsic "pioneering activity", or if all TFs have the potential to function as PFs within certain cellular contexts. There are also different views regarding the key feature(s) that define pioneering activity. In this review, we present evidence from the literature related to these alternative views and discuss how to potentially reconcile them. It is possible that both intrinsic properties, like tight nucleosome binding and structural compatibility, and cellular conditions, like concentration and co-factor availability, are important for PF function.

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来源期刊
CiteScore
14.90
自引率
0.00%
发文量
6
期刊介绍: As the discipline of biochemistry and molecular biology have greatly advanced in the last quarter century, significant contributions have been made towards the advancement of general medicine, genetics, immunology, developmental biology, and biophysics. Investigators in a wide range of disciplines increasingly require an appreciation of the significance of current biochemical and molecular biology advances while, members of the biochemical and molecular biology community itself seek concise information on advances in areas remote from their own specialties. Critical Reviews in Biochemistry and Molecular Biology believes that well-written review articles prove an effective device for the integration and meaningful comprehension of vast, often contradictory, literature. Review articles also provide an opportunity for creative scholarship by synthesizing known facts, fruitful hypotheses, and new concepts. Accordingly, Critical Reviews in Biochemistry and Molecular Biology publishes high-quality reviews that organize, evaluate, and present the current status of high-impact, current issues in the area of biochemistry and molecular biology. Topics are selected on the advice of an advisory board of outstanding scientists, who also suggest authors of special competence. The topics chosen are sufficiently broad to interest a wide audience of readers, yet focused enough to be within the competence of a single author. Authors are chosen based on their activity in the field and their proven ability to produce a well-written publication.
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