国槐的抗氧化活性及其强效提取物的脂质体开发

IF 1.9 Q3 PHARMACOLOGY & PHARMACY Drug Discoveries and Therapeutics Pub Date : 2024-07-09 Epub Date: 2024-05-22 DOI:10.5582/ddt.2024.01018
Soraya Rodwattanagul, Mathurada Sasarom, Pornthida Riangjanapatee, Songyot Anuchapreeda, Siriporn Okonogi
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引用次数: 0

摘要

Sophora exigua(SE)依次用正己烷、乙酸乙酯和乙醇提取。对获得的提取物进行了抗氧化活性测试。其中,分馏乙酸乙酯提取物(SE-EA)在清除自由基和还原铁元素方面表现出最高的潜力。化学分析确定槐黄烷酮 G 是 SE-EA 的活性成分之一。根据 SE-EA 的溶解性,采用超声辅助薄膜法开发了 SE-EA 脂质体。脂质体的主要成分是胆固醇和磷脂。所获得的脂质体呈球形,其纳米尺寸范围、尺寸分布和 Zeta 电位因 SE-EA 和总脂质浓度的不同而不同。SE-EA 脂质体比空脂质体略大。所有脂质体都呈现磷脂结晶结构。胆固醇和SE-EA以无定形状态存在于脂质体中。总脂质含量高的 SE-EA 脂质体具有较高的包载效率和持续释放特性。而总脂质含量低的脂质体则表现出较低的夹带效率和快速释放特性。与未包封的 SE-EA 相比,所有 SE-EA 脂质体都表现出更强的抗氧化活性。总之,SE-EA 是一种天然的强效抗氧化剂。所开发的 SE-EA 脂质体是一种很有前景的药物制剂,能有效地传递 SE-EA 的活性成分,适合在体内进行进一步研究。
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Antioxidant activity of Sophora exigua and liposome development of its powerful extract.

Sophora exigua (SE) was sequentially extracted using hexane, ethyl acetate, and ethanol. The obtained extracts were tested for antioxidant activity. Among them, the fractionated ethyl acetate extract (SE-EA) showed the highest potential in free radical scavenging and ferric-reducing properties. The chemical analysis identified sophoraflavanone G as one of the active ingredients in SE-EA. According to SE-EA solubility, SE-EA liposomes were developed using a sonication-assisted thin film method. Cholesterol and phospholipids were used as the main compositions of the liposomes. The obtained liposomes were spherical with different nano-size ranges, size distribution, and zeta potential depending on SE-EA and total lipid concentrations. SE-EA liposomes were slightly bigger than their empty liposomes. All liposomes exhibited a phospholipid crystalline structure. Cholesterol and SE-EA existed in the liposomes as an amorphous state. SE-EA liposomes with high total lipid content exhibited high entrapment efficiency and sustained release behavior. Whereas liposomes with low total lipid content showed low entrapment efficiency and fast-release behavior. All SE-EA liposomes showed stronger antioxidant activity than the non-entrapped SE-EA. In conclusion, SE-EA is a natural source of potent antioxidants. The developed SE-EA liposomes are a promising pharmaceutical formulation to efficiently deliver the active ingredients of SE-EA and are suitable for further study in vivo.

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来源期刊
Drug Discoveries and Therapeutics
Drug Discoveries and Therapeutics PHARMACOLOGY & PHARMACY-
CiteScore
3.20
自引率
3.20%
发文量
51
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