[肝脏肿瘤的立体定向放射治疗]。

Revue medicale de Liege Pub Date : 2024-05-01
Alexandre Taillez, Isaure Roquette
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引用次数: 0

摘要

肝脏病变在肿瘤学中很常见,可采用各种病灶治疗方法,如手术、化疗栓塞、射频和全身治疗。然而,这些治疗方法往往不可行,原因有很多,包括患者的总体健康状况或病灶本身的特点。此外,病灶治疗后可能会出现局部复发。过去,肝脏放射治疗因其毒性而受到限制,主要用于姑息治疗或移植前的特殊治疗。然而,高精度放疗技术的进步,如立体定向条件下的低分次放疗,使得治疗病灶时边缘最小化,在提供更大剂量的同时减少了健康肝脏的照射剂量。越来越多的回顾性和前瞻性研究表明,低分量放疗对原发性和继发性肝脏病变均有效且安全。本综述将讨论这种治疗方法的适应症、效果和技术。
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[Stereotactic radiation therapy for liver tumours].

Liver lesions are common in oncology, and various focal treatments can be used, such as surgery, chemoembolization, radiofrequency, and systemic treatment. However, these treatments are often not feasible for a number of reasons, including the patient's general health or the characteristics of the lesion itself. Additionally, localized relapses may occur after focal treatments. In the past, liver radiotherapy was limited by the toxicities it caused and was mainly used in palliative situations or specific pre-transplant management. However, advancements in high-precision radiotherapy, like hypofractionated radiotherapy in stereotactic conditions, have allowed to treat the lesions with minimal margins, delivering higher doses while reducing the healthy liver's exposure. Increasingly, retrospective and prospective studies have demonstrated the effectiveness and safety of hypofractionation for both primary and secondary liver lesions. This review discusses the indications, results, and techniques of this type of treatment.

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