确定苯磺酸瑞马唑仑联合阿芬太尼用于成人胃镜检查的 ED50 和 ED95：一项前瞻性剂量探索研究。

IF 1.7 4区医学 Q2 ANESTHESIOLOGY Brazilian Journal of Anesthesiology Pub Date : 2024-05-23 DOI:10.1016/j.bjane.2024.844518

Pingjuan Wang, Song Xue, Liufei Zhang, Kunkun Gao, Yiqiao Wang

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引用次数: 0

摘要

背景：探讨苯磺酸瑞马唑仑与阿芬太尼联合用于成人胃镜检查的中位有效剂量（ED50）和95%有效剂量（ED95）：探讨苯磺酸雷马唑仑联合阿芬太尼用于成人胃镜检查的中位有效剂量（ED50）和95%有效剂量（ED95）：这项前瞻性研究在2022年4月至5月期间在安徽省第二人民医院登记了31例计划进行无痛胃镜检查的患者。镇痛前使用 5 µg.kg-1 的盐酸阿芬太尼。苯乙酸瑞马唑仑的初始单次负荷剂量为0.12 mg.kg-1，采用改良的Dixon序列法为下一位患者增加或减少0.01 mg.kg-1。采用改良的观察者警觉性/镇静评估量表（MOAA/S）评估镇静效果：结果：与阿芬太尼联用，苯磺酸瑞马唑仑的 ED50 为 0.147 mg.kg-1（95% CI：0.138-0.160 mg.kg-1），ED95 为 0.171 mg.kg-1（95% CI：0.159-0.245 mg.kg-1）。注射苯磺酸雷马唑仑后的诱导时间为（70±25）秒，麻醉恢复时间和复苏室观察时间分别为（5.13±2.13）分钟和（2.32±1.6）分钟：结论：苯乙酸瑞马唑仑联合阿芬太尼用于无痛胃镜检查的ED50为0.147 mg.kg-1，ED95为0.171 mg.kg-1。

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Determination of ED50 and ED95 of remimazolam besylate combined with alfentanil for adult gastroscopy: a prospective dose-finding study

Background

To explore the median effective dose (ED50) and 95% effective dose (ED95) of remimazolam besylate combined with alfentanil for adult gastroscopy.

Methods

This prospective studyenrolled 31 patients scheduled to painless gastroscopy at Anhui No. 2 Provincial People's Hospital between April and May, 2022. 5 µg.kg⁻¹ of alfentanil hydrochloride was used for pre-analgesia. The initial single loading dose of remimazolam besylate was 0.12 mg.kg⁻¹, increased or reduced by 0.01 mg.kg⁻¹ for the next patient with modified Dixon sequential method. The modified Observer's Assessment of Alertness/Sedation Scale (MOAA/S) was used to assess sedation.

Results

Combined with alfentanil, the ED50 of remimazolam besylate was 0.147 mg.kg⁻¹ (95% CI: 0.138-0.160 mg.kg⁻¹) and ED95 0.171 mg.kg⁻¹ (95% CI: 0.159-0.245 mg.kg⁻¹). The induction time after injection of remimazolam besylate was 70 ± 25 s, with the anesthesia recovery time and the observation time in resuscitation room 5.13 ± 2.13 min and 2.32 ± 1.6 min, respectively. Twenty nine patients’ vital signs were within acceptable limits during gastroscopy.