将中性粒细胞与淋巴细胞比率作为社区老年人的营养指标进行评估

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Archives of Medical Research Pub Date : 2024-05-24 DOI:10.1016/j.arcmed.2024.103003
Miguel Germán Borda , Pablo Lafuente Sanchis , Jonathan Patricio Baldera , Francisco José Tarazona-Santabalbina , Diego Andrés Chavarro-Carvajal , Salomón Salazar-Londoño , Mariia Bocharova , Dag Aarsland , Antonio Martín-Marco
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引用次数: 0

摘要

背景在老龄化人口中,人们越来越需要易于获取的营养指标。目的确定与迷你营养评估简表(MNA-SF)或白蛋白和体重指数(BMI)等其他常见指标相比,中性粒细胞与淋巴细胞比率(NLR)能否作为有效的营养指标。这项横断面研究收集了全面的数据,包括人口统计学、健康相关因素和身体评估。中性粒细胞和淋巴细胞计数通过全血细胞计数进行测量。通过 MNA-SF 评估营养状况,并计算体重指数。为评估参与者的功能状况,还进行了多项体能测试。最终样本包括 1790 名受试者(48.9% 为男性)。总体年龄中位数为 68 岁(IQR 64-76)。女性的体重指数和淋巴细胞较高,而男性的 NLR 较高。MNA-SF 与 NLR 呈负相关。同样,淋巴细胞计数与 MNA-SF 呈正相关。研究结果表明,NLR 和淋巴细胞与营养状况之间存在显著关系。NLR与白蛋白的相关性强于与体重指数的相关性。NLR 的简便性和可负担性可能使其适用于多个医学领域的常规应用,从而提高我们对营养、炎症和整体健康之间复杂关系的认识。
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Assessing Neutrophil-to-Lymphocyte Ratio as a Nutritional Indicator in Community-Dwelling Older Adults

Background

In an aging population, there is an increasing need for easily accessible nutritional markers.

Aims

To determine whether the neutrophil-to-lymphocyte ratio (NLR) can serve as an effective nutritional indicator compared to the Mini-Nutritional Assessment Short Form (MNA-SF) or other common markers such as albumin and body mass index (BMI).

Methods

Data were obtained from the SABE study in Ecuador, which included participants aged 60 years or older. This cross-sectional study collected comprehensive data, including demographics, health-related factors, and physical assessments. Neutrophil and lymphocyte counts were measured by complete blood count. Nutritional status was assessed by MNA-SF, and BMI was calculated. Several physical tests were performed to evaluate the participants’ functional status. Confounding variables such as age, sex, and comorbidities were considered.

Results

The final sample consisted of 1790 subjects (48.9% male). The overall median age was 68 years (IQR 64,76). BMI and lymphocytes were higher in females, while NLR was higher in males. MNA-SF showed a negative association with NLR. Similarly, lymphocyte count shows a positive association with MNA-SF. Physical tests, such as the Romberg test and the Five Times Sit-to-Stand test, also showed correlations with NLR and lymphocyte count, respectively.

Conclusion

The study results suggest a significant relationship between NLR and lymphocytes, and nutritional status. The correlation with albumin is stronger with NLR than with BMI. The simplicity and affordability of NLR may make it suitable for routine use in several medical fields, improving our understanding of the complex relationship between nutrition, inflammation, and overall health.

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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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