系统化学的多化学问题

IF 3.1 Q2 CHEMISTRY, MULTIDISCIPLINARY ChemSystemsChem Pub Date : 2024-05-22 DOI:10.1002/syst.202400027
Dr. Oliver R. Maguire
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引用次数: 0

摘要

一个大肠杆菌细胞含有约 2500 种不同的化学物质,这些化学物质组合成一个有序的生化反应网络,从中产生一个生命系统。化学家从实验室的化学柜中取出 2500 种不同的化学物质并将它们结合在一起,很可能会引发爆炸性灾难,产生难以处理的化学淤泥。系统化学渴望构建复杂程度可与生命相媲美的系统。然而,要做到这一点,我们需要学会如何将成百上千种不同的化学物质组合在一起,形成一个功能系统,而不至于沦为无序的化学淤泥。这就是系统化学的多化学问题。我将探讨生命克服这一挑战的关键策略。即把动力学上稳定、热力学上活化的分子(如 ATP)与酶催化剂(如组氨酸激酶)结合起来。我提出了这一策略如何可能始于生命起源。最后,我将评估这一策略对系统化学的影响,以及它将如何使系统化学家构建出复杂程度可与生命媲美的系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Many-Chemicals Problem of Systems Chemistry

An E. coli cell contains ~2500 different chemicals which combine into an ordered biochemical reaction network out of which emerges a living system. A chemist taking 2500 different chemicals from a laboratory chemical cabinet and combining them together will likely cause an explosive disaster and produce an intractable chemical sludge. Systems Chemistry aspires to construct systems whose complexity rivals that of life. However, to do this we will need to learn how to combine hundreds or thousands of different chemicals together to form a functional system without descending into a disordered chemical sludge. This is the Many-Chemicals Problem of Systems Chemistry. I explore a key strategy life employs to overcome this challenge. Namely, the combination of kinetically stable and thermodynamically activated molecules (e. g. ATP) with enzyme catalysts (e. g. histidine kinases). I suggest how the strategy could have begun at the origin of life. Finally, I assess the implications of this strategy for Systems Chemistry and how it will enable systems chemists to construct systems whose complexity rivals that of life.

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