评估暴露于偶氮染料掺假棕榈油的白化大鼠的肾功能和血脂概况

Kola-Ajibade I. R., Ajibola E., Jegede R. J., Olusola A.
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引用次数: 0

摘要

食品是人类生存的一个重要因素,因此,接触食品中的掺假物质是挑战生物系统的一个重要环境因素。在西非,棕榈油的生产和加工没有适当的卫生监测,因此几乎不可能发现系统中的欺诈行为。在棕榈油中使用掺杂物的一个主要缺点是,这些掺杂物没有经过充分研究,也不知道食用后会对人体健康造成多大危害。本研究旨在评估掺有偶氮染料的棕榈油对接触过掺有偶氮染料的棕榈油的白化大鼠的肾功能和血脂的毒性影响。研究人员将 25 只白化大鼠分为 5 组,分别进行以下处理:第一组(对照组)、第二组和第三组分别只用 1 毫升/千克未掺假和掺假棕榈油处理,第四组和第五组分别只用 50 毫克/千克苏丹Ⅲ号和Ⅳ号染料处理 28 天。使用分析测试试剂盒测定肾功能测试和血脂概况。所得数据用 Graph Pad prism 9.0.0 进行单因素方差分析(ANOVA)和 tukey 检验进行统计分析,结果以平均值 ± 平均值标准误差(SEM)表示。在 95% 的置信区间内,处理组和对照组的平均值之间的差异 P≤0.05 即为显著。结果表明,与对照组相比,用掺假棕榈油、苏丹 III 和苏丹 IV 处理的组别(分别为组别 III、IV 和 V)的肌酐、尿素浓度、钠离子(Na+)和钾离子(K+)明显增加(P < 0.05)。与对照组相比,处理组的低密度脂蛋白(LDL)、胆固醇、极低密度脂蛋白(VLDL)和三酰甘油(TAG)含量明显增加(p < 0.05),而与对照组相比,处理组的高密度脂蛋白(HDL)含量明显下降(p < 0.05)。这表明掺假棕榈油可诱发肾损伤并改变血脂状况。
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Assessment of Kidney Function and Lipid Profile in Albino Rats Exposed to Azo-Dye Adulterated Palm Oil
Food is an important factor in human existence which makes exposure to adulterants in food an important environmental factor challenging the biological system. In West Africa, the manufacturing and processing of palm oil are done without proper hygienic monitoring; it is therefore almost impossible to detect fraud in the system. A major disadvantage associated with the use of adulterants in palm oil is that the adulterants have not undergone adequate research and the degree of health hazards they can pose to humans when consumed. This study was designed to evaluate the toxic effects of Azo dye adulterated palm oil on kidney function and Lipid profile in albino rats exposed to Azo-dye adulterated palm oil. Twenty-five albino rats were divided into five groups and treated as thus: Group I (control), Groups II and III were treated with only 1 ml/kg of unadulterated and adulterated palm oil respectively, while Groups IV and V were treated with only 50 mg/kg of Sudan III and IV dyes respectively for 28 days. Renal function tests, and lipid profiles were determined using analytical test kits. Data obtained were statistically analyzed with one-way analysis of variance (ANOVA) followed by tukey test using Graph Pad prism 9.0.0. The results were presented as mean ± standard error of mean (SEM). Differences between means of treated and control groups values at P ≤ 0.05 at 95% confidence interval were considered significant. The results showed a significant increase (p < 0.05) in creatinine, urea concentrations, Sodium ion (Na+) and Potassium ion (K+) in groups treated with adulterated palm oil, Sudan III, Sudan IV (groups III, IV and V respectively) when compared with control groups. A significant increase (p < 0.05) in low density lipoprotein (LDL), cholesterol, very low-density lipoprotein (VLDL) and Triacylglycerol (TAG) was observed in treated groups when compared with control groups while a significant decrease (p < 0.05) in high density lipoprotein level (HDL) observed in treated groups when compared with the control group. This suggests that adulterated palm oil can induce renal damage and alter lipid profile.
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