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{"title":"FKBP52 激活的 NFAT 通过抑制 p53 促进癌细胞增殖","authors":"Shunsuke Hanaki, M. Habara, Haruki Tomiyasu, Yuki Sato, Yosei Miki, T. Masaki, Shusaku Shibutani, M. Shimada","doi":"10.26508/lsa.202302426","DOIUrl":null,"url":null,"abstract":"FKBP52 promotes nuclear translocation of NFATc, which activates MDM2 transcription, thus suppressing p53 expression and promoting cell proliferation.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"NFAT activation by FKBP52 promotes cancer cell proliferation by suppressing p53\",\"authors\":\"Shunsuke Hanaki, M. Habara, Haruki Tomiyasu, Yuki Sato, Yosei Miki, T. Masaki, Shusaku Shibutani, M. Shimada\",\"doi\":\"10.26508/lsa.202302426\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"FKBP52 promotes nuclear translocation of NFATc, which activates MDM2 transcription, thus suppressing p53 expression and promoting cell proliferation.\",\"PeriodicalId\":18081,\"journal\":{\"name\":\"Life Science Alliance\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Life Science Alliance\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.26508/lsa.202302426\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life Science Alliance","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.26508/lsa.202302426","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
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