将晚期肺癌炎症指数和非酒精性脂肪肝纤维化评分结合起来，作为肝细胞癌外科手术选择的有望标记物

IF 2.9 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Annals of Gastroenterological Surgery Pub Date : 2024-05-20 DOI:10.1002/ags3.12815

Kiyotaka Hosoda, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Noriyuki Kitagawa, Takahiro Yoshizawa, Hiroki Sakai, Hikaru Hayashi, Koya Yasukawa, Yuji Soejima

{"title":"将晚期肺癌炎症指数和非酒精性脂肪肝纤维化评分结合起来，作为肝细胞癌外科手术选择的有望标记物","authors":"Kiyotaka Hosoda, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Noriyuki Kitagawa, Takahiro Yoshizawa, Hiroki Sakai, Hikaru Hayashi, Koya Yasukawa, Yuji Soejima","doi":"10.1002/ags3.12815","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>Methods of predicting severe postoperative complications after anatomical resection for hepatocellular carcinoma are yet to be established. We aimed to clarify the relationship between inflammation-based prognostic scores and liver fibrosis markers and the incidence of postoperative complications after anatomical resection for hepatocellular carcinoma as well as the usefulness of these markers in surgical procedure selection.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We included 374 patients with hepatocellular carcinoma who had undergone initial hepatectomy between January 2007 and December 2021. The association between inflammation-based prognostic scores or liver fibrosis markers and postoperative complications was evaluated, and severe postoperative complication rates in the high-risk group defined by these markers were compared in terms of surgical procedure.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score correlated significantly with severe postoperative complications after anatomical resection, with areas under the curve of 0.67 and 0.61, respectively. The combined advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score resulted in a larger area under the curve (0.69). Furthermore, in the high-risk group determined by the combined score, the anatomical resection group had a significantly higher incidence of severe complications than the partial resection group (<i>P <</i> 0.01). There were no significant differences in prognosis among the surgical procedures in the high-risk group.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The combined advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score serves as a predictive marker for severe postoperative complications after anatomical resection. This combined marker may contribute to appropriate surgical procedure selection.</p>\n </section>\n </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":"8 6","pages":"1096-1106"},"PeriodicalIF":2.9000,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12815","citationCount":"0","resultStr":"{\"title\":\"Combination of advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score as a promising marker for surgical procedure selection for hepatocellular carcinoma\",\"authors\":\"Kiyotaka Hosoda, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Noriyuki Kitagawa, Takahiro Yoshizawa, Hiroki Sakai, Hikaru Hayashi, Koya Yasukawa, Yuji Soejima\",\"doi\":\"10.1002/ags3.12815\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>Methods of predicting severe postoperative complications after anatomical resection for hepatocellular carcinoma are yet to be established. We aimed to clarify the relationship between inflammation-based prognostic scores and liver fibrosis markers and the incidence of postoperative complications after anatomical resection for hepatocellular carcinoma as well as the usefulness of these markers in surgical procedure selection.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We included 374 patients with hepatocellular carcinoma who had undergone initial hepatectomy between January 2007 and December 2021. The association between inflammation-based prognostic scores or liver fibrosis markers and postoperative complications was evaluated, and severe postoperative complication rates in the high-risk group defined by these markers were compared in terms of surgical procedure.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score correlated significantly with severe postoperative complications after anatomical resection, with areas under the curve of 0.67 and 0.61, respectively. The combined advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score resulted in a larger area under the curve (0.69). Furthermore, in the high-risk group determined by the combined score, the anatomical resection group had a significantly higher incidence of severe complications than the partial resection group (<i>P <</i> 0.01). There were no significant differences in prognosis among the surgical procedures in the high-risk group.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The combined advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score serves as a predictive marker for severe postoperative complications after anatomical resection. This combined marker may contribute to appropriate surgical procedure selection.</p>\\n </section>\\n </div>\",\"PeriodicalId\":8030,\"journal\":{\"name\":\"Annals of Gastroenterological Surgery\",\"volume\":\"8 6\",\"pages\":\"1096-1106\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12815\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Gastroenterological Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ags3.12815\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Gastroenterological Surgery","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ags3.12815","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

预测肝细胞癌解剖切除术后严重并发症的方法尚未建立。我们旨在阐明基于炎症的预后评分和肝纤维化标志物与肝细胞癌解剖切除术后并发症发生率之间的关系，以及这些标志物在手术方法选择中的作用。我们评估了基于炎症的预后评分或肝纤维化标志物与术后并发症之间的关联，并比较了由这些标志物定义的高风险组的严重术后并发症发生率与手术方式的关系。晚期肺癌炎症指数和非酒精性脂肪肝肝纤维化评分与解剖切除术后严重术后并发症显著相关，曲线下面积分别为0.67和0.61。晚期肺癌炎症指数和非酒精性脂肪肝纤维化评分的曲线下面积更大（0.69）。此外，在根据综合评分确定的高风险组中，解剖切除组的严重并发症发生率明显高于部分切除组（P < 0.01）。晚期肺癌炎症指数和非酒精性脂肪肝纤维化综合评分可作为解剖切除术后严重并发症的预测指标。这一综合指标可能有助于选择适当的手术方式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Combination of advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score as a promising marker for surgical procedure selection for hepatocellular carcinoma

Aim

Methods of predicting severe postoperative complications after anatomical resection for hepatocellular carcinoma are yet to be established. We aimed to clarify the relationship between inflammation-based prognostic scores and liver fibrosis markers and the incidence of postoperative complications after anatomical resection for hepatocellular carcinoma as well as the usefulness of these markers in surgical procedure selection.

Methods

We included 374 patients with hepatocellular carcinoma who had undergone initial hepatectomy between January 2007 and December 2021. The association between inflammation-based prognostic scores or liver fibrosis markers and postoperative complications was evaluated, and severe postoperative complication rates in the high-risk group defined by these markers were compared in terms of surgical procedure.

Results

The advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score correlated significantly with severe postoperative complications after anatomical resection, with areas under the curve of 0.67 and 0.61, respectively. The combined advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score resulted in a larger area under the curve (0.69). Furthermore, in the high-risk group determined by the combined score, the anatomical resection group had a significantly higher incidence of severe complications than the partial resection group (P < 0.01). There were no significant differences in prognosis among the surgical procedures in the high-risk group.

Conclusion

The combined advanced lung cancer inflammation index and nonalcoholic fatty liver disease fibrosis score serves as a predictive marker for severe postoperative complications after anatomical resection. This combined marker may contribute to appropriate surgical procedure selection.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊