更正：卟啉过度驱动重塑癌细胞新陈代谢

IF 4.7 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-05-20 DOI:10.26508/lsa.202402816

S. Adapa, Gregory A Hunter, Narmin E. Amin, Christopher Marinescu, Andrew Borsky, Elizabeth M Sagatys, Said M. Sebti, Gary W. Reuther, Gloria C Ferreira, R. H. Jiang

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引用次数: 0

摘要

癌细胞表现出一种被称为 "卟啉超速 "的代谢表型，其特点是中间体积累的血红素代谢途径失调。这种重新布线是癌症所必需的，也是癌症所特有的。利用 "诱杀 "策略瞄准这一弱点，有望根除恶性细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Correction: Porphyrin overdrive rewires cancer cell metabolism

Cancer cells exhibit a metabolic phenotype termed “porphyrin overdrive,” characterized by dysregulated heme metabolic pathways for intermediate accumulation. This rewiring is cancer-essential and cancer-specific. Targeting this vulnerability with a “bait-and-kill” strategy shows promise in eradicating malignant cells.

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico