微小核糖核酸在垂体促性腺激素细胞中的作用

IF 2.1 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM General and comparative endocrinology Pub Date : 2024-05-24 DOI:10.1016/j.ygcen.2024.114557
He Zou , Peimin Wang , Jinglin Zhang
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引用次数: 0

摘要

垂体内的促性腺激素细胞通过分泌促卵泡激素(FSH)和促黄体生成素(LH)来控制重要的生殖过程。外部刺激和内部调节因素都有助于调节促性腺激素的发育和功能。近年来,越来越多的证据表明,转录后调控基因表达的微RNA(miRNA)在性腺发育和功能的多个过程中发挥着关键作用,包括FSH和LH的α或β亚基的合成、LH的分泌、GnRH信号的调控以及性腺细胞动力学的维持。在此,我们通过使用 miRNA 基因敲除小鼠模型、硅学分析以及原代垂体细胞和促性腺激素衍生细胞系的体外培养,回顾了 miRNA 的表达、功能和机制的最新进展。通过总结和讨论 miRNAs 在促性腺激素中的不同作用,本微综述有助于深入了解促性腺激素和生殖中复杂的分子网络。
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Role of microRNAs in pituitary gonadotrope cells

The gonadotrope cells within the pituitary control vital processes of reproduction by producing follicle stimulating hormone (FSH) and luteinizing hormone (LH). Both external stimuli and internal regulatory factors contribute to the regulation of gonadotrope development and function. In recent years, growing evidences indicate that microRNAs (miRNAs), which regulate gene expression post-transcriptionally, play critical roles in multiple processes of gonadotrope development and function, including the syntheses of α or β subunits of FSH and LH, the secretion of LH, the regulation of GnRH signaling, and the maintenance of gonadotrope cell kinetics. Here, we review recent advances of miRNAs’ expression, functions and mechanisms approached by using miRNA knockout mouse models, in silico analysis and the in vitro cultures of primary pituitary cells and gonadotrope-derived cell lines. By summarizing and discussing different roles of miRNAs in gonadotropes, this minireview helps to gain insights into the complex molecular network in gonadotropes and reproduction.

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来源期刊
General and comparative endocrinology
General and comparative endocrinology 医学-内分泌学与代谢
CiteScore
5.60
自引率
7.40%
发文量
120
审稿时长
2 months
期刊介绍: General and Comparative Endocrinology publishes articles concerned with the many complexities of vertebrate and invertebrate endocrine systems at the sub-molecular, molecular, cellular and organismal levels of analysis.
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