与重组 FSH 相比,使用高纯度 HMG 刺激卵巢时血清孕酮较低,原因是对卵泡类固醇生成的调节不同:随机对照试验

Ernesto Bosch, P. Alamá, Josep Lluis Romero, Marta Marı, E. Labarta, Antonio Pellicer
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引用次数: 0

摘要

(摘自《人类生殖》2024;39:393-402)卵巢刺激(OS)后的血清孕酮水平与周期结果(持续妊娠率和活产率)有关,孕酮水平超过一定阈值时,周期结果较差。孕酮的增加与卵巢反应和促排卵过程中的 FSH 剂量呈正相关;但这一机制尚不十分清楚。
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Serum Progesterone Is Lower in Ovarian Stimulation With Highly Purified HMG Compared to Recombinant FSH Owing to a Different Regulation of Follicular Steroidogenesis: A Randomized Controlled Trial
(Abstracted from Hum Reprod 2024;39:393–402 Serum progesterone levels following ovarian stimulation (OS) are associated with the cycle result in terms of ongoing pregnancy and live birth rate, with levels above a certain threshold associated with poorer results. An increase in progesterone is positively associated with the ovarian response and the FSH dose administered during OS; however, this mechanism is not well understood.
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