脂肪组织来源干细胞移植 5 年后的皮肤淀粉样变性状况

Kazuo Shigematsu , Takahisa Takeda , Naoyuki Komori , Kenich Tahara , Hisakazu Yamagishi
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摘要

我们曾报道过一例皮肤淀粉样变性病例,患者在接受脂肪组织源性干细胞(ADSC)治疗后病情有所好转。本报告对同一部位的皮肤淀粉样变性沉积状况进行了为期五年的随访,显示自首次报告以来病情持续好转。患者是一名皮肤病学教授,他对几十年来逐渐发展的淀粉样蛋白沉积意外消失深表满意。然而,考虑到患者没有接受干预治疗,在服用 ADSC 后的两个月内病情持续好转,以及报告中与 ADSC 相关的异常蛋白降解酶活性,自然的解释是服用 ADSC 与皮肤淀粉样变性好转之间存在潜在的相关性。虽然将疗效完全归因于 ADSCs 还需谨慎,但没有其他特定治疗方法以及 ADSCs 的酶活性记录都支持这一假设。这一点尤其重要,因为 ADSCs 除了对皮肤淀粉样变性病有潜在影响外,还有望成为一种新型治疗方法,用于治疗缺乏明确治疗方法的进行性神经退行性疾病。了解 ADSC 作用的持续时间和可持续性对于评估 ADSC 在皮肤淀粉样变性病和神经退行性疾病领域的广泛应用至关重要。本病例强调了进一步研究 ADSCs 作为一种新型治疗方法在具有挑战性的进展性疾病中的潜力的必要性。
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Skin amyloidosis status 5 years after adipose tissue-derived stem cell transplantation

We previously reported a case of skin amyloidosis showing improvement after adipose tissue-derived stem cell (ADSC) therapy. This report provides a five-year follow-up on the status of the same site of skin amyloid deposition, demonstrating continued improvement since the initial report. The patient, a dermatology professor, expressed profound satisfaction with the unexpected disappearance of amyloid deposits that had been progressing gradually over several decades. While the cause of this sudden regression remains unclear, attributing it definitively to the effects of ADSCs is challenging.

However, given the absence of interventions, the consistent improvement over the two months following ADSC administration, and the reported abnormal protein-degrading enzyme activity associated with ADSCs, a natural interpretation suggests a potential correlation between ADSC administration and skin amyloidosis improvement. Although caution is warranted in attributing the effects solely to ADSCs, the absence of other specific treatments and the documented enzymatic activities of ADSCs support this hypothesis.

While acknowledging the speculative nature of associating the observed effects with ADSCs, the enduring positive response raises intriguing questions about the duration of ADSC efficacy. This is particularly relevant as ADSCs, beyond their potential impact on skin amyloidosis, hold promise as a novel therapeutic approach for progressive neurodegenerative disorders lacking definitive treatment methods.

Understanding the duration and sustainability of ADSC effects is crucial for evaluating their broader applications, not only in skin amyloidosis but also in the realm of neurodegenerative diseases. This case underscores the need for further investigation into the potential of ADSCs as a novel therapeutic avenue in the context of challenging and progressive medical conditions.

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