{"title":"磷酸盐缓冲盐水中 MTA 加壳聚糖和 MTA 加壳聚糖共轭物生物活性的比较评估--一项无创研究","authors":"","doi":"10.1016/j.sdentj.2024.05.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and Objective</h3><p>Various materials like MTA, Biodentine etc have been used for the regeneration of lost dental tissues. Still, the quest for newer materials to enhance the bioactivity of the existing materials continues. Hence this study aims at the evaluation of bioactivity of MTA Plus when conjugated with Chitosan in phosphate buffer saline.</p></div><div><h3>Methodology</h3><p>Materials used were MTA Plus (Group 1), MTA Plus and chitosan conjugate(Group 2). The materials were mixed and placed in phosphate buffer saline. Bioactivity of Group 1 and Group 2 materials were assessed at 7 days and 28 day’s time intervals using SEM-EDX analysis.</p></div><div><h3>Results</h3><p>SEM analysis of group 1 revealed a compact and agglomerate lath-like appearance with uniform particle size. SEM analysis of group 2 reveals acicular and lath-like appearance of the precipitate on the material surface. EDX analysis of the freshly prepared materials gave the qualitative semiquantitative elemental composition on the material surfaces after immersion in PBS for 7 and 28 days.</p></div><div><h3>Conclusion</h3><p>MTA Plus Chitosan conjugate had greater potential to form apatite crystals on its surface. Hence, Chitosan can be used as a vehicle for the currently available materials to enhance the bioactivity and fasten the healing process.</p></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1013905224001548/pdfft?md5=c995ea6d7d4e5d9d2303788684c8f824&pid=1-s2.0-S1013905224001548-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Comparative evaluation of bioactivity of MTA plus and MTA plus chitosan conjugate in phosphate buffer saline an invitro study\",\"authors\":\"\",\"doi\":\"10.1016/j.sdentj.2024.05.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and Objective</h3><p>Various materials like MTA, Biodentine etc have been used for the regeneration of lost dental tissues. Still, the quest for newer materials to enhance the bioactivity of the existing materials continues. Hence this study aims at the evaluation of bioactivity of MTA Plus when conjugated with Chitosan in phosphate buffer saline.</p></div><div><h3>Methodology</h3><p>Materials used were MTA Plus (Group 1), MTA Plus and chitosan conjugate(Group 2). The materials were mixed and placed in phosphate buffer saline. Bioactivity of Group 1 and Group 2 materials were assessed at 7 days and 28 day’s time intervals using SEM-EDX analysis.</p></div><div><h3>Results</h3><p>SEM analysis of group 1 revealed a compact and agglomerate lath-like appearance with uniform particle size. SEM analysis of group 2 reveals acicular and lath-like appearance of the precipitate on the material surface. EDX analysis of the freshly prepared materials gave the qualitative semiquantitative elemental composition on the material surfaces after immersion in PBS for 7 and 28 days.</p></div><div><h3>Conclusion</h3><p>MTA Plus Chitosan conjugate had greater potential to form apatite crystals on its surface. Hence, Chitosan can be used as a vehicle for the currently available materials to enhance the bioactivity and fasten the healing process.</p></div>\",\"PeriodicalId\":47246,\"journal\":{\"name\":\"Saudi Dental Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1013905224001548/pdfft?md5=c995ea6d7d4e5d9d2303788684c8f824&pid=1-s2.0-S1013905224001548-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Saudi Dental Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1013905224001548\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Saudi Dental Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1013905224001548","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
背景和目的MTA、Biodentine 等多种材料已被用于牙体组织的再生。然而，人们仍在继续寻找更新的材料来增强现有材料的生物活性。因此，本研究旨在评估 MTA Plus 与壳聚糖结合后在磷酸盐缓冲盐水中的生物活性。方法所用材料为 MTA Plus（第 1 组）、MTA Plus 和壳聚糖结合物（第 2 组）。材料混合后置于磷酸盐缓冲盐水中。通过 SEM-EDX 分析，在 7 天和 28 天的时间间隔内对第 1 组和第 2 组材料的生物活性进行了评估。第 2 组的 SEM 分析显示，材料表面的沉淀物呈针状和板条状。在 PBS 中浸泡 7 天和 28 天后，对新鲜制备的材料进行的 EDX 分析给出了材料表面的定性半定量元素组成。因此，壳聚糖可用作现有材料的载体，以增强生物活性并加快愈合过程。
Comparative evaluation of bioactivity of MTA plus and MTA plus chitosan conjugate in phosphate buffer saline an invitro study
Background and Objective
Various materials like MTA, Biodentine etc have been used for the regeneration of lost dental tissues. Still, the quest for newer materials to enhance the bioactivity of the existing materials continues. Hence this study aims at the evaluation of bioactivity of MTA Plus when conjugated with Chitosan in phosphate buffer saline.
Methodology
Materials used were MTA Plus (Group 1), MTA Plus and chitosan conjugate(Group 2). The materials were mixed and placed in phosphate buffer saline. Bioactivity of Group 1 and Group 2 materials were assessed at 7 days and 28 day’s time intervals using SEM-EDX analysis.
Results
SEM analysis of group 1 revealed a compact and agglomerate lath-like appearance with uniform particle size. SEM analysis of group 2 reveals acicular and lath-like appearance of the precipitate on the material surface. EDX analysis of the freshly prepared materials gave the qualitative semiquantitative elemental composition on the material surfaces after immersion in PBS for 7 and 28 days.
Conclusion
MTA Plus Chitosan conjugate had greater potential to form apatite crystals on its surface. Hence, Chitosan can be used as a vehicle for the currently available materials to enhance the bioactivity and fasten the healing process.
期刊介绍：
Saudi Dental Journal is an English language, peer-reviewed scholarly publication in the area of dentistry. Saudi Dental Journal publishes original research and reviews on, but not limited to: • dental disease • clinical trials • dental equipment • new and experimental techniques • epidemiology and oral health • restorative dentistry • periodontology • endodontology • prosthodontics • paediatric dentistry • orthodontics and dental education Saudi Dental Journal is the official publication of the Saudi Dental Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.
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