{"title":"向人类脂质体计划迈进--推进结构脂质组学的发展","authors":"Junhan Wu , Wenpeng Zhang , Zheng Ouyang","doi":"10.1016/j.trac.2024.117765","DOIUrl":null,"url":null,"abstract":"<div><p>Comprehensive characterization of lipidomes is highly desirable for fundamental biological study as well as for disease biomarker screening. As highly complementary to the genomics and proteomics, lipidomics provides important information related to lipidomes and enables their correlations to genomes and proteomes. During the past few years, significant progresses have been made in instrumentation and analytical method for elucidating detailed structural features of lipids. In this review, the current status of the lipidomics with higher structural specificity is surveyed and its capacity as well as existing challenges are discussed in terms of supporting future human lipidome project, which is expected to be the next important step for human omics study.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.8000,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Marching toward human lipidome project – Advancement of structural lipidomics\",\"authors\":\"Junhan Wu , Wenpeng Zhang , Zheng Ouyang\",\"doi\":\"10.1016/j.trac.2024.117765\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Comprehensive characterization of lipidomes is highly desirable for fundamental biological study as well as for disease biomarker screening. As highly complementary to the genomics and proteomics, lipidomics provides important information related to lipidomes and enables their correlations to genomes and proteomes. During the past few years, significant progresses have been made in instrumentation and analytical method for elucidating detailed structural features of lipids. In this review, the current status of the lipidomics with higher structural specificity is surveyed and its capacity as well as existing challenges are discussed in terms of supporting future human lipidome project, which is expected to be the next important step for human omics study.</p></div>\",\"PeriodicalId\":439,\"journal\":{\"name\":\"Trends in Analytical Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":11.8000,\"publicationDate\":\"2024-05-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Analytical Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165993624002486\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Analytical Chemistry","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165993624002486","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Marching toward human lipidome project – Advancement of structural lipidomics
Comprehensive characterization of lipidomes is highly desirable for fundamental biological study as well as for disease biomarker screening. As highly complementary to the genomics and proteomics, lipidomics provides important information related to lipidomes and enables their correlations to genomes and proteomes. During the past few years, significant progresses have been made in instrumentation and analytical method for elucidating detailed structural features of lipids. In this review, the current status of the lipidomics with higher structural specificity is surveyed and its capacity as well as existing challenges are discussed in terms of supporting future human lipidome project, which is expected to be the next important step for human omics study.
期刊介绍：
TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.
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