Ramona Ramalho de Souza Pereira, Giselle Bicalho de Castro, Caíque Olegário Diniz e Magalhães, Karine Beatriz Costa, Bruna Caroline Chaves Garcia, Gabriela Silva, Jaqueline do Carmo Lima Carvalho, Alan Rodrigues Teixeira Machado, Etel Rocha Vieira, Ricardo Cardoso Cassilhas, Luciano José Pereira, Marco Fabrício Dias-Peixoto, Eric Francelino Andrade
{"title":"高强度间歇训练可减轻牙周炎的恶化并改善大鼠的行为。","authors":"Ramona Ramalho de Souza Pereira, Giselle Bicalho de Castro, Caíque Olegário Diniz e Magalhães, Karine Beatriz Costa, Bruna Caroline Chaves Garcia, Gabriela Silva, Jaqueline do Carmo Lima Carvalho, Alan Rodrigues Teixeira Machado, Etel Rocha Vieira, Ricardo Cardoso Cassilhas, Luciano José Pereira, Marco Fabrício Dias-Peixoto, Eric Francelino Andrade","doi":"10.1111/jcpe.14020","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>To investigate the effects of high-intensity interval training (HIIT) on periodontitis (PD) progression and behavioural outcomes.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>Forty-eight Wistar rats were divided into four groups: non-trained (NT); non-trained with PD; HIIT with PD; and HIIT. The HIIT protocol, involving daily treadmill sessions, spanned 8 weeks, with PD induced by ligature after the 6th week. Behavioural tests were conducted to assess anxiety and memory. Post euthanasia, we evaluated the systemic inflammatory profile and oxidative stress markers in the hippocampus and amygdala. A morphological evaluation and elemental composition analysis of the mandibular alveolar bone were performed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>PD exacerbated alveolar bone level, bone surface damage and alterations in calcium and phosphorus percentages on the bone surface (<i>p</i> < .05), while HIIT attenuated these changes (<i>p</i> < .05). HIIT improved systemic inflammatory markers altered by PD (tumour necrosis factor [TNF]-α, interleukin [IL]-10, TNF-α/IL-10 and IL-1β/IL-10 ratios, <i>p</i> < .05). PD animals exhibited lower total antioxidant capacity and levels of thiobarbituric acid reactive substances in the amygdala and hippocampus, respectively (<i>p</i> < .05). HIIT maintained these parameters at levels similar to those in NT animals. HIIT improved anxiety and memory outcomes altered by PD (<i>p</i> < .05).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>HIIT attenuates systemic inflammation, anxiety and memory outcomes promoted by PD.</p>\n </section>\n </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":null,"pages":null},"PeriodicalIF":5.8000,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High-intensity interval training mitigates the progression of periodontitis and improves behavioural aspects in rats\",\"authors\":\"Ramona Ramalho de Souza Pereira, Giselle Bicalho de Castro, Caíque Olegário Diniz e Magalhães, Karine Beatriz Costa, Bruna Caroline Chaves Garcia, Gabriela Silva, Jaqueline do Carmo Lima Carvalho, Alan Rodrigues Teixeira Machado, Etel Rocha Vieira, Ricardo Cardoso Cassilhas, Luciano José Pereira, Marco Fabrício Dias-Peixoto, Eric Francelino Andrade\",\"doi\":\"10.1111/jcpe.14020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>To investigate the effects of high-intensity interval training (HIIT) on periodontitis (PD) progression and behavioural outcomes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Materials and Methods</h3>\\n \\n <p>Forty-eight Wistar rats were divided into four groups: non-trained (NT); non-trained with PD; HIIT with PD; and HIIT. The HIIT protocol, involving daily treadmill sessions, spanned 8 weeks, with PD induced by ligature after the 6th week. Behavioural tests were conducted to assess anxiety and memory. Post euthanasia, we evaluated the systemic inflammatory profile and oxidative stress markers in the hippocampus and amygdala. A morphological evaluation and elemental composition analysis of the mandibular alveolar bone were performed.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>PD exacerbated alveolar bone level, bone surface damage and alterations in calcium and phosphorus percentages on the bone surface (<i>p</i> < .05), while HIIT attenuated these changes (<i>p</i> < .05). HIIT improved systemic inflammatory markers altered by PD (tumour necrosis factor [TNF]-α, interleukin [IL]-10, TNF-α/IL-10 and IL-1β/IL-10 ratios, <i>p</i> < .05). PD animals exhibited lower total antioxidant capacity and levels of thiobarbituric acid reactive substances in the amygdala and hippocampus, respectively (<i>p</i> < .05). HIIT maintained these parameters at levels similar to those in NT animals. HIIT improved anxiety and memory outcomes altered by PD (<i>p</i> < .05).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>HIIT attenuates systemic inflammation, anxiety and memory outcomes promoted by PD.</p>\\n </section>\\n </div>\",\"PeriodicalId\":15380,\"journal\":{\"name\":\"Journal of Clinical Periodontology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.8000,\"publicationDate\":\"2024-05-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Periodontology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jcpe.14020\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Periodontology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jcpe.14020","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
High-intensity interval training mitigates the progression of periodontitis and improves behavioural aspects in rats
Aim
To investigate the effects of high-intensity interval training (HIIT) on periodontitis (PD) progression and behavioural outcomes.
Materials and Methods
Forty-eight Wistar rats were divided into four groups: non-trained (NT); non-trained with PD; HIIT with PD; and HIIT. The HIIT protocol, involving daily treadmill sessions, spanned 8 weeks, with PD induced by ligature after the 6th week. Behavioural tests were conducted to assess anxiety and memory. Post euthanasia, we evaluated the systemic inflammatory profile and oxidative stress markers in the hippocampus and amygdala. A morphological evaluation and elemental composition analysis of the mandibular alveolar bone were performed.
Results
PD exacerbated alveolar bone level, bone surface damage and alterations in calcium and phosphorus percentages on the bone surface (p < .05), while HIIT attenuated these changes (p < .05). HIIT improved systemic inflammatory markers altered by PD (tumour necrosis factor [TNF]-α, interleukin [IL]-10, TNF-α/IL-10 and IL-1β/IL-10 ratios, p < .05). PD animals exhibited lower total antioxidant capacity and levels of thiobarbituric acid reactive substances in the amygdala and hippocampus, respectively (p < .05). HIIT maintained these parameters at levels similar to those in NT animals. HIIT improved anxiety and memory outcomes altered by PD (p < .05).
Conclusions
HIIT attenuates systemic inflammation, anxiety and memory outcomes promoted by PD.
期刊介绍：
Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology.
The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope.
The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.
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