Tingting Ye, Ying Shao, Changwei Cai, Yuchen Li, Bin Yu, Xu Qiao, Chuanteng Feng, Peng Jia, Shujuan Yang
{"title":"PM2.5 化学成分与全身肥胖、腹部肥胖和内脏肥胖的关系以及体育锻炼的调解作用","authors":"Tingting Ye, Ying Shao, Changwei Cai, Yuchen Li, Bin Yu, Xu Qiao, Chuanteng Feng, Peng Jia, Shujuan Yang","doi":"10.1186/s12302-024-00935-4","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The association between exposure to PM<sub>2.5</sub> chemical constituents and obesity remains to be elucidated, as most studies have used a single measure of obesity. This study aimed to investigate the associations of exposure to PM<sub>2.5</sub> chemical constituents with general, abdominal, and visceral obesity, and the mediation effect of physical activity (PA) in the associations.</p><h3>Methods</h3><p>Based on a total of 49,819 adults from the baseline of the Yunnan Behavior and Disease Surveillance cohort (YBDS) in southern China in 2021, we used multiple linear regression, weighted quantile sum regression, and quantile regression to estimate independent and joint effects of PM<sub>2.5</sub> chemical constituents on elevated BMI, waist circumference (WC) and visceral adiposity index (VAI) and whether these effects changed in quantiles. Mediation analysis was used to examine whether physical activity acts as a mediator in these pathways.</p><h3>Results</h3><p>Per IQR μg/m<sup>3</sup> increase in all PM<sub>2.5</sub> chemical constituents was significantly associated with the elevated BMI (β [95% CI]: 0.170 [0.127, 0.214]), WC (0.316 [0.217, 0.415]) and VAI (0.102 [0.075, 0.129]), with the largest weights from OM (53.89, 81.67, and 89.82%, respectively). The effects of PM<sub>2.5</sub> chemical constituents on obesity showed an overall upward trend from quantiles 1–4 of BMI, WC, and VAI, especially with a rapid upward trend from the sixth decile of VAI. Reduced PA mediated 3.16, 7.08, and 3.78% of the associations between PM<sub>2.5</sub> chemical constituents and elevated BMI, WC, and VAI, respectively.</p><h3>Conclusions</h3><p>Exposure to PM<sub>2.5</sub> chemical constituents, especially OM, was significantly associated with increased risks for obesity in adults. The effects of associations increased with obesity severity, with PA playing a mediation role.</p></div>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://enveurope.springeropen.com/counter/pdf/10.1186/s12302-024-00935-4","citationCount":"0","resultStr":"{\"title\":\"Association of PM2.5 chemical constituents with general, abdominal and visceral obesity and mediation roles of physical activity\",\"authors\":\"Tingting Ye, Ying Shao, Changwei Cai, Yuchen Li, Bin Yu, Xu Qiao, Chuanteng Feng, Peng Jia, Shujuan Yang\",\"doi\":\"10.1186/s12302-024-00935-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The association between exposure to PM<sub>2.5</sub> chemical constituents and obesity remains to be elucidated, as most studies have used a single measure of obesity. This study aimed to investigate the associations of exposure to PM<sub>2.5</sub> chemical constituents with general, abdominal, and visceral obesity, and the mediation effect of physical activity (PA) in the associations.</p><h3>Methods</h3><p>Based on a total of 49,819 adults from the baseline of the Yunnan Behavior and Disease Surveillance cohort (YBDS) in southern China in 2021, we used multiple linear regression, weighted quantile sum regression, and quantile regression to estimate independent and joint effects of PM<sub>2.5</sub> chemical constituents on elevated BMI, waist circumference (WC) and visceral adiposity index (VAI) and whether these effects changed in quantiles. Mediation analysis was used to examine whether physical activity acts as a mediator in these pathways.</p><h3>Results</h3><p>Per IQR μg/m<sup>3</sup> increase in all PM<sub>2.5</sub> chemical constituents was significantly associated with the elevated BMI (β [95% CI]: 0.170 [0.127, 0.214]), WC (0.316 [0.217, 0.415]) and VAI (0.102 [0.075, 0.129]), with the largest weights from OM (53.89, 81.67, and 89.82%, respectively). The effects of PM<sub>2.5</sub> chemical constituents on obesity showed an overall upward trend from quantiles 1–4 of BMI, WC, and VAI, especially with a rapid upward trend from the sixth decile of VAI. Reduced PA mediated 3.16, 7.08, and 3.78% of the associations between PM<sub>2.5</sub> chemical constituents and elevated BMI, WC, and VAI, respectively.</p><h3>Conclusions</h3><p>Exposure to PM<sub>2.5</sub> chemical constituents, especially OM, was significantly associated with increased risks for obesity in adults. 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Association of PM2.5 chemical constituents with general, abdominal and visceral obesity and mediation roles of physical activity
Background
The association between exposure to PM2.5 chemical constituents and obesity remains to be elucidated, as most studies have used a single measure of obesity. This study aimed to investigate the associations of exposure to PM2.5 chemical constituents with general, abdominal, and visceral obesity, and the mediation effect of physical activity (PA) in the associations.
Methods
Based on a total of 49,819 adults from the baseline of the Yunnan Behavior and Disease Surveillance cohort (YBDS) in southern China in 2021, we used multiple linear regression, weighted quantile sum regression, and quantile regression to estimate independent and joint effects of PM2.5 chemical constituents on elevated BMI, waist circumference (WC) and visceral adiposity index (VAI) and whether these effects changed in quantiles. Mediation analysis was used to examine whether physical activity acts as a mediator in these pathways.
Results
Per IQR μg/m3 increase in all PM2.5 chemical constituents was significantly associated with the elevated BMI (β [95% CI]: 0.170 [0.127, 0.214]), WC (0.316 [0.217, 0.415]) and VAI (0.102 [0.075, 0.129]), with the largest weights from OM (53.89, 81.67, and 89.82%, respectively). The effects of PM2.5 chemical constituents on obesity showed an overall upward trend from quantiles 1–4 of BMI, WC, and VAI, especially with a rapid upward trend from the sixth decile of VAI. Reduced PA mediated 3.16, 7.08, and 3.78% of the associations between PM2.5 chemical constituents and elevated BMI, WC, and VAI, respectively.
Conclusions
Exposure to PM2.5 chemical constituents, especially OM, was significantly associated with increased risks for obesity in adults. The effects of associations increased with obesity severity, with PA playing a mediation role.
期刊介绍:
ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation.
ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation.
ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation.
Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues.
Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.