利用纳米电机进行口服线粒体移植治疗缺血性心脏病

IF 38.1 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Nature nanotechnology Pub Date : 2024-05-27 DOI:10.1038/s41565-024-01681-7
Ziyu Wu, Lin Chen, Wenyan Guo, Jun Wang, Haiya Ni, Jianing Liu, Wentao Jiang, Jian Shen, Chun Mao, Min Zhou, Mimi Wan
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摘要

线粒体移植是恢复缺血性心脏病(IHD)患者能量供应的重要治疗策略;然而,由于移植方法的侵入性和线粒体活性的丧失,线粒体移植受到了限制。在此,我们报告了口服线粒体移植治疗缺血性心脏病的成功案例。通过对线粒体表面的一氧化氮释放纳米马达进行修饰,获得了纳米马达化线粒体,在纳米马达的作用下,线粒体对受损心脏组织具有趋化靶向能力。纳米马达化的线粒体被包装在肠溶胶囊中,以防止胃酸侵蚀。口服后,线粒体在肠道中释放,迅速被肠道细胞吸收并分泌到血液中,从而输送到受损的心脏组织。纳米线粒体对疾病微环境的调节不仅可以实现受损心肌细胞对线粒体的快速吸收和高度保留,还能保持移植线粒体的高活性。此外,IHD 动物模型的研究结果表明,受损心脏组织中积累的纳米线粒体可在转录水平上调节心脏代谢,从而阻止 IHD 的发展。这种策略有可能改变用于治疗 IHD 的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Oral mitochondrial transplantation using nanomotors to treat ischaemic heart disease
Mitochondrial transplantation is an important therapeutic strategy for restoring energy supply in patients with ischaemic heart disease (IHD); however, it is limited by the invasiveness of the transplantation method and loss of mitochondrial activity. Here we report successful mitochondrial transplantation by oral administration for IHD therapy. A nitric-oxide-releasing nanomotor is modified on the mitochondria surface to obtain nanomotorized mitochondria with chemotactic targeting ability towards damaged heart tissue due to nanomotor action. The nanomotorized mitochondria are packaged in enteric capsules to protect them from gastric acid erosion. After oral delivery the mitochondria are released in the intestine, where they are quickly absorbed by intestinal cells and secreted into the bloodstream, allowing delivery to the damaged heart tissue. The regulation of disease microenvironment by the nanomotorized mitochondria can not only achieve rapid uptake and high retention of mitochondria by damaged cardiomyocytes but also maintains high activity of the transplanted mitochondria. Furthermore, results from animal models of IHD indicate that the accumulated nanomotorized mitochondria in the damaged heart tissue can regulate cardiac metabolism at the transcriptional level, thus preventing IHD progression. This strategy has the potential to change the therapeutic strategy used to treat IHD. Ischaemic heart disease, which poses a severe threat to human health, is characterized by mitochondria damage and energy metabolism disorder. Here mitochondria were orally transplanted to the heart using nanomotors to restore energy metabolism by non-invasive administration.
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来源期刊
Nature nanotechnology
Nature nanotechnology 工程技术-材料科学:综合
CiteScore
59.70
自引率
0.80%
发文量
196
审稿时长
4-8 weeks
期刊介绍: Nature Nanotechnology is a prestigious journal that publishes high-quality papers in various areas of nanoscience and nanotechnology. The journal focuses on the design, characterization, and production of structures, devices, and systems that manipulate and control materials at atomic, molecular, and macromolecular scales. It encompasses both bottom-up and top-down approaches, as well as their combinations. Furthermore, Nature Nanotechnology fosters the exchange of ideas among researchers from diverse disciplines such as chemistry, physics, material science, biomedical research, engineering, and more. It promotes collaboration at the forefront of this multidisciplinary field. The journal covers a wide range of topics, from fundamental research in physics, chemistry, and biology, including computational work and simulations, to the development of innovative devices and technologies for various industrial sectors such as information technology, medicine, manufacturing, high-performance materials, energy, and environmental technologies. It includes coverage of organic, inorganic, and hybrid materials.
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