Shengnan Liu, Hao Wang, Jiaoyang Li, Jingtao Gao, Li Yu, Xiaofei Wei, Mengchao Cui, Yuxin Zhao, Yinming Liang, Hui Wang
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引用次数: 0
摘要
M1/M2 巨噬细胞极化在调节组织内微环境平衡方面发挥着重要作用。此外,巨噬细胞极化还涉及葡萄糖和脂质代谢等新陈代谢的重编程。转录辅激活因子 B 细胞淋巴瘤-3(Bcl-3)是 IκB 家族的非典型成员,它通过调节核因子卡巴 B 通路的激活来控制巨噬细胞中的炎症因子水平。然而,Bcl-3 与巨噬细胞极化和新陈代谢之间的关系仍不清楚。在这项研究中,我们发现巨噬细胞中 Bcl-3 的敲除可通过促进核因子卡巴 B 通路的激活来调节糖酵解相关基因的表达。此外,Bcl-3的缺失还能通过加速糖酵解促进γ干扰素/脂多糖诱导的M1巨噬细胞极化。综上所述,这些结果表明,Bcl-3 可能是调节巨噬细胞 M1 极化的候选基因。
Loss of Bcl-3 regulates macrophage polarization by promoting macrophage glycolysis
M1/M2 macrophage polarization plays an important role in regulating the balance of the microenvironment within tissues. Moreover, macrophage polarization involves the reprogramming of metabolism, such as glucose and lipid metabolism. Transcriptional coactivator B-cell lymphoma-3 (Bcl-3) is an atypical member of the IκB family that controls inflammatory factor levels in macrophages by regulating nuclear factor kappa B pathway activation. However, the relationship between Bcl-3 and macrophage polarization and metabolism remains unclear. In this study, we show that the knockdown of Bcl-3 in macrophages can regulate glycolysis-related gene expression by promoting the activation of the nuclear factor kappa B pathway. Furthermore, the loss of Bcl-3 was able to promote the interferon gamma/lipopolysaccharide-induced M1 macrophage polarization by accelerating glycolysis. Taken together, these results suggest that Bcl-3 may be a candidate gene for regulating M1 polarization in macrophages.
期刊介绍:
The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.