性早熟的基础和 FSH 刺激抑制素 B

IF 1.7 4区医学 Q2 PEDIATRICS Indian pediatrics Pub Date : 2024-08-15 Epub Date: 2024-05-25

Shakun Chaudhary, Rama Walia, Anil Bhansali, Devi Dayal, Naresh Sachdeva, Tulika Singh, Sanjay Kumar Bhadada

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引用次数: 0

摘要

目的评估基础和卵泡刺激素（FSH）刺激抑制素 B 在区分早熟和促性腺激素依赖性性早熟（GDPP）方面的作用：这是一项前瞻性干预研究。方法：这是一项前瞻性干预研究，对初潮年龄小于 8 岁的女孩（10 人）、青春期发育正常的健康女孩（青春期对照组）（8 人）和青春期前的健康女孩（青春期前对照组）（7 人）的基础和 FSH 刺激抑制素 B 水平进行估计。根据 GnRH 激动剂刺激试验，将青春期提前的女孩分为早熟或 GDPP：早熟少女基础抑制素 B 的中位数（IQR）为 5.42 (2.91, 30.58) pg/mL，FSH 刺激抑制素 B 的中位数（IQR）为 236.72 (111.53, 4431.73) pg/mL（P = 0.043）。GDPP 的基础抑制素 B 中位数（IQR）为 64.11 (24.96, 792.45) pg/mL，FSH 刺激的抑制素 B 为 833.66 (500.11-1266.18) pg/mL（P = 0.043）。基础抑制素 B 可区分 GDPP 和早孕（P = 0.032）。青春期前和青春期前对照组的基础抑制素 B 中位数（IQR）分别为 20.36 (9.61, 29.12) pg/mL 和 75.48 (58.55, 165.55) pg/mL：基础抑制素B有助于区分早孕和GDPP，而FSH刺激的抑制素B的作用则需要在大样本量中进一步探讨。

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Basal and FSH-stimulated Inhibin B in Precocious Puberty.

Objective: To evaluate the role of basal and follicle-stimulating hormone (FSH)-stimulated inhibin B in differentiating premature thelarche from gonadotropin-dependent precocious puberty (GDPP).

Methods: This was a prospective interventional study. Basal and FSH-stimulated inhibin B levels were estimated in girls presenting with thelarche < 8 years age (n = 10), healthy girls with normal pubertal development (pubertal control) (n = 8) and healthy prepubertal girls (prepubertal control) (n = 7). Girls with early puberty were classified as premature thelarche or GDPP based on GnRH agonist stimulation test.

Results: Median (IQR) basal inhibin B levels (pg/mL) in premature thelarche was 5.42 (2.91, 30.58) and FSH-stimulated inhibin B was 236.72 (111.53, 4431.73) (P = 0.043). Median (IQR) basal inhibin B in GDPP was 64.11 (24.96, 792.45) pg/mL and FSH-stimulated inhibin B was 833.66 (500.11-1266.18) pg/mL (P = 0.043). Basal inhibin B was discriminatory between GDPP and premature thelarche (P = 0.032). Median (IQR) basal inhibin B in prepubertal and pubertal controls was 20.36 (9.61, 29.12) and 75.48 (58.55, 165.55) pg/mL, respectively.

Conclusion: Basal inhibin B is useful in differentiation of premature thelarche from GDPP while the role of FSH-stimulated inhibin B needs to be further explored in large sample size.

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.