通过简单设计实现近零颗粒生成--用于洁净室环境的基于兼容机械装置的机械手。

IF 2.5 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS SLAS Technology Pub Date : 2024-05-25 DOI:10.1016/j.slast.2024.100148
Leon Budde, Jakob Hentschel, Sontje Ihler, Thomas Seel
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引用次数: 0

摘要

实验室自动化促进了高通量流程,提高了可重复性和效率,同时消除了人为操作这一污染颗粒的主要来源。由于与物体的密切接触,操作过程会带来污染风险。我们提出了一种新型机械手(CrocoGrip),它依靠顺从机制来减少机械手产生的污染颗粒数量,而不是阻止其排放,后者是当前机械手的常用方法。我们的新型机械手由线性电磁铁驱动,完全依靠变形来实现运动。因此,在无需额外密封的情况下,可以减少磨损行为,从而减少颗粒的产生。我们的实验证明,只有小于 3.0µm 的微粒才会由机械手释放出来,而大部分微粒都是由驱动装置产生的。CrocoGrip 符合 ISO14644 第 5 级的要求。抓取依靠的是顺从机构的变形能,因此抓取既节能又安全。CrocoGrip 实现的最大抓取力为 5.5N。由于传送到搬运物体上的力取决于夹爪的设计,而夹爪是可以互换的,因此可以降低力以更合理地搬运物体。通过使用三组不同的夹钳,CrocoGrip 能够使用机械臂处理 SBS 标准的微孔板、50 毫升的猎鹰试管和直径 60 毫米的培养皿。由于 CrocoGrip 采用整体式设计,只需很少的组件,因此设计简单,即使非专业人员也能轻松完成清洁、消毒和维护工作。CrocoGrip 充分利用了顺从机构的优势,尤其适用于需要洁净室环境的应用。这种基于顺从机构的机械手可在不增加机械手系统复杂性的情况下提高处理过程的清洁度,从而促进组织工程等高敏感过程的实验室自动化。
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Achieving near-zero particle generation by simplicity of design—A compliant-mechanism-based gripper for clean-room environments

Lab Automation facilitates high-throughput processes and improves reproducibility and efficiency while removing human action, primary source of contaminating particles. Handling poses a risk of contamination due to close contact with the objects. We propose a novel gripper (CrocoGrip) relying on compliant mechanisms to reduce the amount of contaminating particles generated by the gripper rather than preventing their emission, the latter being the common approach in current grippers. Our novel gripper is actuated by linear solenoids and purely relies on deformation for its motion. As a result, abrasive behavior and, therefore, the generation of particles is reduced without the need for additional sealing. We experimentally proved that only particles smaller than 3.0 µm are emitted by the gripper, with a large proportion of the particles being generated by the actuation. The CrocoGrip fulfills the demands of ISO14644 class 5. The gripping relies on the deformation energy of the compliant mechanism, making the gripping energy-efficient and safe. The maximum gripping force achieved by the CrocoGrip was 5.5 N. Because the force transmitted to the handling object depends on the design of the gripping jaws, which are interchangeable, the force can be reduced for more sensible handling objects. Using three different sets of jaws, CrocoGrip was able to handle a microplate in SBS-standard, a 50 mL Falcon tube, and a Ø60 mm Petri dish using a robotic arm. Due to the monolithic design of the CrocoGrip and, as a result, the need for few components, we achieve a simplicity of design, making cleaning, sterilization and maintenance easy, even for nonexperts. The CrocoGrip exploits the advantages of compliant mechanisms, especially for applications requiring clean-room environments. This approach of compliant-mechanism-based grippers enables an increase in the cleanliness of handling processes without an increase in system complexity of the gripper to facilitate the lab automation of highly sensible processes, such as in tissue engineering.

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来源期刊
SLAS Technology
SLAS Technology Computer Science-Computer Science Applications
CiteScore
6.30
自引率
7.40%
发文量
47
审稿时长
106 days
期刊介绍: SLAS Technology emphasizes scientific and technical advances that enable and improve life sciences research and development; drug-delivery; diagnostics; biomedical and molecular imaging; and personalized and precision medicine. This includes high-throughput and other laboratory automation technologies; micro/nanotechnologies; analytical, separation and quantitative techniques; synthetic chemistry and biology; informatics (data analysis, statistics, bio, genomic and chemoinformatics); and more.
期刊最新文献
Model-Based Interactive Visualization for Complex Systems Requirements and Design in Joint Tests. Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discovery. Life Sciences Discovery and Technology Highlights. Notes on AEMS methods development for high throughput experimentation in drug discovery. Prosthesis repair of oral implants based on artificial intelligenc`e finite element analysis.
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