Georgios P Skandalakis, Clemens Neudorfer, Caitlin A Payne, Evalina Bond, Armin D Tavakkoli, Jessica Barrios-Martinez, Anne C Trutti, Christos Koutsarnakis, Volker A Coenen, Spyridon Komaitis, Constantinos G Hadjipanayis, George Stranjalis, Fang-Cheng Yeh, Layla Banihashemi, Jennifer Hong, Andres M Lozano, Michael Kogan, Andreas Horn, Linton T Evans, Aristotelis Kalyvas
{"title":"通过对中脑刺激相关神经回路的显微解剖建立连接。","authors":"Georgios P Skandalakis, Clemens Neudorfer, Caitlin A Payne, Evalina Bond, Armin D Tavakkoli, Jessica Barrios-Martinez, Anne C Trutti, Christos Koutsarnakis, Volker A Coenen, Spyridon Komaitis, Constantinos G Hadjipanayis, George Stranjalis, Fang-Cheng Yeh, Layla Banihashemi, Jennifer Hong, Andres M Lozano, Michael Kogan, Andreas Horn, Linton T Evans, Aristotelis Kalyvas","doi":"10.1093/brain/awae173","DOIUrl":null,"url":null,"abstract":"<p><p>Comprehensive understanding of the neural circuits involving the ventral tegmental area is essential for elucidating the anatomofunctional mechanisms governing human behaviour, in addition to the therapeutic and adverse effects of deep brain stimulation for neuropsychiatric diseases. Although the ventral tegmental area has been targeted successfully with deep brain stimulation for different neuropsychiatric diseases, the axonal connectivity of the region is not fully understood. Here, using fibre microdissections in human cadaveric hemispheres, population-based high-definition fibre tractography and previously reported deep brain stimulation hotspots, we find that the ventral tegmental area participates in an intricate network involving the serotonergic pontine nuclei, basal ganglia, limbic system, basal forebrain and prefrontal cortex, which is implicated in the treatment of obsessive-compulsive disorder, major depressive disorder, Alzheimer's disease, cluster headaches and aggressive behaviours.</p>","PeriodicalId":9063,"journal":{"name":"Brain","volume":null,"pages":null},"PeriodicalIF":10.6000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370807/pdf/","citationCount":"0","resultStr":"{\"title\":\"Establishing connectivity through microdissections of midbrain stimulation-related neural circuits.\",\"authors\":\"Georgios P Skandalakis, Clemens Neudorfer, Caitlin A Payne, Evalina Bond, Armin D Tavakkoli, Jessica Barrios-Martinez, Anne C Trutti, Christos Koutsarnakis, Volker A Coenen, Spyridon Komaitis, Constantinos G Hadjipanayis, George Stranjalis, Fang-Cheng Yeh, Layla Banihashemi, Jennifer Hong, Andres M Lozano, Michael Kogan, Andreas Horn, Linton T Evans, Aristotelis Kalyvas\",\"doi\":\"10.1093/brain/awae173\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Comprehensive understanding of the neural circuits involving the ventral tegmental area is essential for elucidating the anatomofunctional mechanisms governing human behaviour, in addition to the therapeutic and adverse effects of deep brain stimulation for neuropsychiatric diseases. Although the ventral tegmental area has been targeted successfully with deep brain stimulation for different neuropsychiatric diseases, the axonal connectivity of the region is not fully understood. Here, using fibre microdissections in human cadaveric hemispheres, population-based high-definition fibre tractography and previously reported deep brain stimulation hotspots, we find that the ventral tegmental area participates in an intricate network involving the serotonergic pontine nuclei, basal ganglia, limbic system, basal forebrain and prefrontal cortex, which is implicated in the treatment of obsessive-compulsive disorder, major depressive disorder, Alzheimer's disease, cluster headaches and aggressive behaviours.</p>\",\"PeriodicalId\":9063,\"journal\":{\"name\":\"Brain\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":10.6000,\"publicationDate\":\"2024-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370807/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/brain/awae173\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/brain/awae173","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Establishing connectivity through microdissections of midbrain stimulation-related neural circuits.
Comprehensive understanding of the neural circuits involving the ventral tegmental area is essential for elucidating the anatomofunctional mechanisms governing human behaviour, in addition to the therapeutic and adverse effects of deep brain stimulation for neuropsychiatric diseases. Although the ventral tegmental area has been targeted successfully with deep brain stimulation for different neuropsychiatric diseases, the axonal connectivity of the region is not fully understood. Here, using fibre microdissections in human cadaveric hemispheres, population-based high-definition fibre tractography and previously reported deep brain stimulation hotspots, we find that the ventral tegmental area participates in an intricate network involving the serotonergic pontine nuclei, basal ganglia, limbic system, basal forebrain and prefrontal cortex, which is implicated in the treatment of obsessive-compulsive disorder, major depressive disorder, Alzheimer's disease, cluster headaches and aggressive behaviours.
期刊介绍:
Brain, a journal focused on clinical neurology and translational neuroscience, has been publishing landmark papers since 1878. The journal aims to expand its scope by including studies that shed light on disease mechanisms and conducting innovative clinical trials for brain disorders. With a wide range of topics covered, the Editorial Board represents the international readership and diverse coverage of the journal. Accepted articles are promptly posted online, typically within a few weeks of acceptance. As of 2022, Brain holds an impressive impact factor of 14.5, according to the Journal Citation Reports.