Bogdan R. Brutiu, Le Tang, Daniel Kaiser, Nuno Maulide
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Tetrahydropyran synthesis mediated by catalytic triflic acid and hexafluoroisopropanol
A Brønsted acid-catalyzed regioselective intramolecular hydroalkoxylation is described. This reaction proceeds via a carbocation intermediate and enables the preparation of 1,1,1’-trisubstituted tetrahydropyran derivatives under mild conditions using catalytic triflic acid (TfOH) and hexafluoroisopropanol (HFIP) as a mediator.
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