Di Zhang, Yu Guan, Xiuxiu Zhou, Mingzi Zhang, Yu Pu, Pengchen Gu, Yi Xia, Yang Lu, Jia Chen, Wenting Tu, Kunyao Huang, Jixin Hou, Hua Yang, Chicheng Fu, Qu Fang, Chuan He, Shiyuan Liu, Li Fan
{"title":"小气道阻力的空气动力学模拟：慢性阻塞性肺病的新成像生物标记物","authors":"Di Zhang, Yu Guan, Xiuxiu Zhou, Mingzi Zhang, Yu Pu, Pengchen Gu, Yi Xia, Yang Lu, Jia Chen, Wenting Tu, Kunyao Huang, Jixin Hou, Hua Yang, Chicheng Fu, Qu Fang, Chuan He, Shiyuan Liu, Li Fan","doi":"10.2147/copd.s456878","DOIUrl":null,"url":null,"abstract":"<strong>Purpose:</strong> To develop a novel method for calculating small airway resistance using computational fluid dynamics (CFD) based on CT data and evaluate its value to identify COPD.<br/><strong>Patients and Methods:</strong> 24 subjects who underwent chest CT scans and pulmonary function tests between August 2020 and December 2020 were enrolled retrospectively. Subjects were divided into three groups: normal (10), high-risk (6), and COPD (8). The airway from the trachea down to the sixth generation of bronchioles was reconstructed by a 3D slicer. The small airway resistance (R<sub>SA</sub>) and R<sub>SA</sub> as a percentage of total airway resistance (R<sub>SA</sub>%) were calculated by CFD combined with airway resistance and FEV<sub>1</sub> measured by pulmonary function test. A correlation analysis was conducted between R<sub>SA</sub> and pulmonary function parameters, including FEV<sub>1</sub>/FVC, FEV<sub>1</sub>% predicted, MEF50% predicted, MEF75% predicted and MMEF75/25% predicted.<br/><strong>Results:</strong> The R<sub>SA</sub> and R<sub>SA</sub>% were significantly different among the three groups (p< 0.05) and related to FEV<sub>1</sub>/FVC (r = − 0.70, p < 0.001; r = − 0.67, p < 0.001), FEV<sub>1</sub>% predicted (r = − 0.60, p = 0.002; r = − 0.57, p = 0.004), MEF50% predicted (r = − 0.64, p = 0.001; r = − 0.64, p = 0.001), MEF75% predicted (r = − 0.71, p < 0.001; r = − 0.60, p = 0.002) and MMEF 75/25% predicted (r = − 0.64, p = 0.001; r = − 0.64, p = 0.001).<br/><strong>Conclusion:</strong> Airway CFD is a valuable method for estimating the small airway resistance, where the derived R<sub>SA</sub> will aid in the early diagnosis of COPD.<br/><br/><strong>Keywords:</strong> COPD, small airway disease, CT, fluid dynamics<br/>","PeriodicalId":13792,"journal":{"name":"International Journal of Chronic Obstructive Pulmonary Disease","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aerodynamic Simulation of Small Airway Resistance: A New Imaging Biomarker for Chronic Obstructive Pulmonary Disease\",\"authors\":\"Di Zhang, Yu Guan, Xiuxiu Zhou, Mingzi Zhang, Yu Pu, Pengchen Gu, Yi Xia, Yang Lu, Jia Chen, Wenting Tu, Kunyao Huang, Jixin Hou, Hua Yang, Chicheng Fu, Qu Fang, Chuan He, Shiyuan Liu, Li Fan\",\"doi\":\"10.2147/copd.s456878\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>Purpose:</strong> To develop a novel method for calculating small airway resistance using computational fluid dynamics (CFD) based on CT data and evaluate its value to identify COPD.<br/><strong>Patients and Methods:</strong> 24 subjects who underwent chest CT scans and pulmonary function tests between August 2020 and December 2020 were enrolled retrospectively. Subjects were divided into three groups: normal (10), high-risk (6), and COPD (8). The airway from the trachea down to the sixth generation of bronchioles was reconstructed by a 3D slicer. The small airway resistance (R<sub>SA</sub>) and R<sub>SA</sub> as a percentage of total airway resistance (R<sub>SA</sub>%) were calculated by CFD combined with airway resistance and FEV<sub>1</sub> measured by pulmonary function test. A correlation analysis was conducted between R<sub>SA</sub> and pulmonary function parameters, including FEV<sub>1</sub>/FVC, FEV<sub>1</sub>% predicted, MEF50% predicted, MEF75% predicted and MMEF75/25% predicted.<br/><strong>Results:</strong> The R<sub>SA</sub> and R<sub>SA</sub>% were significantly different among the three groups (p< 0.05) and related to FEV<sub>1</sub>/FVC (r = − 0.70, p < 0.001; r = − 0.67, p < 0.001), FEV<sub>1</sub>% predicted (r = − 0.60, p = 0.002; r = − 0.57, p = 0.004), MEF50% predicted (r = − 0.64, p = 0.001; r = − 0.64, p = 0.001), MEF75% predicted (r = − 0.71, p < 0.001; r = − 0.60, p = 0.002) and MMEF 75/25% predicted (r = − 0.64, p = 0.001; r = − 0.64, p = 0.001).<br/><strong>Conclusion:</strong> Airway CFD is a valuable method for estimating the small airway resistance, where the derived R<sub>SA</sub> will aid in the early diagnosis of COPD.<br/><br/><strong>Keywords:</strong> COPD, small airway disease, CT, fluid dynamics<br/>\",\"PeriodicalId\":13792,\"journal\":{\"name\":\"International Journal of Chronic Obstructive Pulmonary Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Chronic Obstructive Pulmonary Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/copd.s456878\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Chronic Obstructive Pulmonary Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/copd.s456878","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Aerodynamic Simulation of Small Airway Resistance: A New Imaging Biomarker for Chronic Obstructive Pulmonary Disease
Purpose: To develop a novel method for calculating small airway resistance using computational fluid dynamics (CFD) based on CT data and evaluate its value to identify COPD. Patients and Methods: 24 subjects who underwent chest CT scans and pulmonary function tests between August 2020 and December 2020 were enrolled retrospectively. Subjects were divided into three groups: normal (10), high-risk (6), and COPD (8). The airway from the trachea down to the sixth generation of bronchioles was reconstructed by a 3D slicer. The small airway resistance (RSA) and RSA as a percentage of total airway resistance (RSA%) were calculated by CFD combined with airway resistance and FEV1 measured by pulmonary function test. A correlation analysis was conducted between RSA and pulmonary function parameters, including FEV1/FVC, FEV1% predicted, MEF50% predicted, MEF75% predicted and MMEF75/25% predicted. Results: The RSA and RSA% were significantly different among the three groups (p< 0.05) and related to FEV1/FVC (r = − 0.70, p < 0.001; r = − 0.67, p < 0.001), FEV1% predicted (r = − 0.60, p = 0.002; r = − 0.57, p = 0.004), MEF50% predicted (r = − 0.64, p = 0.001; r = − 0.64, p = 0.001), MEF75% predicted (r = − 0.71, p < 0.001; r = − 0.60, p = 0.002) and MMEF 75/25% predicted (r = − 0.64, p = 0.001; r = − 0.64, p = 0.001). Conclusion: Airway CFD is a valuable method for estimating the small airway resistance, where the derived RSA will aid in the early diagnosis of COPD.
Keywords: COPD, small airway disease, CT, fluid dynamics
期刊介绍：
An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals
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