Jesse P. M. Viana, Fernanda F. Costa, Tatielle G. Dias, Priscila M. Mendes, Gabriel B. Copeland, Willian S. Nascimento, Sofia S. N. Mendes, Isabella F. S. Figueiredo, Elizabeth S. Fernandes, Anamelia L. Bocca, Márcia C. G. Maciel
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引用次数: 0
摘要
败血症治疗因其复杂性而具有挑战性，它涉及宿主对严重且可能致命的感染的炎症反应，并伴有器官功能障碍。本研究旨在分析有关葡聚糖在通过盲肠结扎和穿刺诱导的小鼠全身感染模型中的免疫调节作用的科学文献。本研究包括基于系统步骤的综合文献综述，在 PubMed、ScienceDirect、Scopus、Web of Science 和 Embase 数据库中进行了检索。在大多数研究中，调查的主要葡聚糖类型是 β-葡聚糖，剂量为 50 毫克/千克，结果发现它能减轻炎症反应，最大限度地减少组织损伤的发生，从而提高动物的存活率。根据本综述所获得和讨论的数据，葡聚糖是一种很有前景的调节免疫反应的生物技术替代品，有可能用于败血症患者的临床治疗。
Glucans: A Therapeutic Alternative for Sepsis Treatment
Sepsis treatment is a challenging condition due to its complexity, which involves host inflammatory responses to a severe and potentially fatal infection, associated with organ dysfunction. The aim of this study was to analyze the scientific literature on the immunomodulatory effects of glucans in a murine model of systemic infection induced by cecal ligation and puncture. This study comprises an integrative literature review based on systematic steps, with searches carried out in the PubMed, ScienceDirect, Scopus, Web of Science, and Embase databases. In most studies, the main type of glucan investigated was β-glucan, at 50 mg/kg, and a reduction of inflammatory responses was identified, minimizing the occurrence of tissue damage leading to increased animal survival. Based on the data obtained and discussed in this review, glucans represent a promising biotechnological alternative to modulate the immune response and could potentially be used in the clinical management of septic individuals.
期刊介绍：
Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
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