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引用次数: 0
摘要
核酸技术为疫苗开发带来了革命性的变化，可快速设计和生产用于预防和治疗疾病的 RNA 和 DNA 疫苗。针对 COVID-19 的 mRNA 和质粒 DNA 疫苗的成功应用进一步验证了该技术的有效性。目前，mRNA 平台因其更高的效力而占据主导地位，而 DNA 平台则因其独特的优势有可能克服与 mRNA 平台相关的问题而正在迅速发展。为了帮助了解这两种疫苗平台的近期表现并认识到它们在未来的临床潜力，本综述从开发时间、财务成本、销售难易程度、疗效、安全性和产品的监管审批等方面比较了目前文献中已知的 mRNA 和 DNA 疫苗的优缺点。此外，该综述还讨论了正在进行的临床试验、改进策略以及用于疫苗接种的 RNA 和 DNA 平台的替代设计。
A comprehensive comparison of DNA and RNA vaccines
Nucleic acid technology has revolutionized vaccine development, enabling rapid design and production of RNA and DNA vaccines for prevention and treatment of diseases. The successful deployment of mRNA and plasmid DNA vaccines against COVID-19 has further validated the technology. At present, mRNA platform is prevailing due to its higher efficacy, while DNA platform is undergoing rapid evolution because it possesses unique advantages that can potentially overcome the problems associated with the mRNA platform. To help understand the recent performances of the two vaccine platforms and recognize their clinical potentials in the future, this review compares the advantages and drawbacks of mRNA and DNA vaccines that are currently known in the literature, in terms of development timeline, financial cost, ease of distribution, efficacy, safety, and regulatory approval of products. Additionally, the review discusses the ongoing clinical trials, strategies for improvement, and alternative designs of RNA and DNA platforms for vaccination.
期刊介绍：
The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery.
In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.
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