利用气道模型研究人类呼吸系统疾病中的肺神经内分泌细胞。

IF 4 3区 医学 Q2 CELL BIOLOGY Disease Models & Mechanisms Pub Date : 2024-05-01 Epub Date: 2024-05-30 DOI:10.1242/dmm.050620
Noah Candeli, Talya Dayton
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引用次数: 0

摘要

尽管肺神经内分泌细胞(PNECs)只占肺上皮细胞的 0.5%,但它们似乎在呼吸系统健康和疾病中扮演着重要角色。据报道,在包括慢性阻塞性肺病和哮喘在内的多种呼吸系统疾病中,肺神经内分泌细胞的数量都有所增加。此外,PNEC 是肺神经内分泌癌的主要起源细胞,占侵袭性肺癌的 25%。最近的研究突显了 PNECs 在肺生理学中的关键作用,包括化学传感、再生和免疫调节。然而,人们对 PNECs 对呼吸系统疾病的直接影响知之甚少。在这篇综述中,我们总结了目前 PNECs 与肺部病变的关系,重点关注新的实验性疾病模型,如从人类多能干细胞或组织干细胞中提取的器官组织,如何帮助我们更好地了解 PNECs 对呼吸系统疾病的贡献。
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Investigating pulmonary neuroendocrine cells in human respiratory diseases with airway models.

Despite accounting for only ∼0.5% of the lung epithelium, pulmonary neuroendocrine cells (PNECs) appear to play an outsized role in respiratory health and disease. Increased PNEC numbers have been reported in a variety of respiratory diseases, including chronic obstructive pulmonary disease and asthma. Moreover, PNECs are the primary cell of origin for lung neuroendocrine cancers, which account for 25% of aggressive lung cancers. Recent research has highlighted the crucial roles of PNECs in lung physiology, including in chemosensing, regeneration and immune regulation. Yet, little is known about the direct impact of PNECs on respiratory diseases. In this Review, we summarise the current associations of PNECs with lung pathologies, focusing on how new experimental disease models, such as organoids derived from human pluripotent stem cells or tissue stem cells, can help us to better understand the contribution of PNECs to respiratory diseases.

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来源期刊
Disease Models & Mechanisms
Disease Models & Mechanisms 医学-病理学
CiteScore
6.60
自引率
7.00%
发文量
203
审稿时长
6-12 weeks
期刊介绍: Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
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