山楂籽多酚类化合物的 UPLC-ESI-TQD-MS/MS 鉴定及其抗氧化、抗炎、抗糖尿病、抗肥胖和抗癌特性。

IF 3.1 2区 农林科学 Q2 CHEMISTRY, APPLIED Plant Foods for Human Nutrition Pub Date : 2024-09-01 Epub Date: 2024-05-30 DOI:10.1007/s11130-024-01197-4
Natalia Żurek, Michał Świeca, Ireneusz Kapusta
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引用次数: 0

摘要

山楂籽是水果加工的副产品,由于这种原材料的加工规模较大,因此可以成为生物活性化合物的重要来源。本研究首次报道了山楂种子的酚类成分及其抗氧化、抗炎、抗糖尿病、抗肥胖和抗癌活性。采用 UPLC-ESI-TQD-MS/MS 方法鉴定了 6 种山楂种子分离出的酚类组分中的 23 种酚类化合物,其中主要包括 B 型原花青素二聚体。被测物种的种子具有很高的抗氧化(主要通过清除 O2 和 OH 自由基)、抗炎(主要通过抑制 LOX)、抗糖尿病、抗肥胖和抗癌活性,其中对结肠癌细胞(Dld-1 株)的活性最高,而对健康的结肠上皮细胞(CCD841CoN)则没有活性。这种活性明显取决于所分析的山楂种类,根据 PCA 分析,还取决于黄烷-3-醇的含量。这些发现为山楂种子的工业应用提供了理论基础。
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UPLC-ESI-TQD-MS/MS Identification and Antioxidant, Anti-Inflammatory, Anti-Diabetic, Anti-Obesity and Anticancer Properties of Polyphenolic Compounds of Hawthorn Seeds.

Hawthorn seeds are a by-product of fruit processing and due to the scale of processing of this raw material, they can be an important source of bioactive compounds. This work is the first report on the phenolic composition of hawthorn seeds and their antioxidant, anti-inflammatory, antidiabetic, antiobesity and anticancer activities. In the isolated phenolic fraction of six seed species, 23 phenolic compounds were identified using the UPLC-ESI-TQD-MS/MS method, the key ones of which included the B-type procyanidin dimer. The seeds of the tested species showed high antioxidant activity (mainly by scavenging O2•- and OH radicals), anti-inflammatory (mainly through LOX inhibition), anti-diabetic, anti-obesity and anti-cancer, with the highest activity against colon cancer cells (Dld-1 line), showing no activity against healthy colon epithelial cells (CCD841CoN). This activity was significantly dependent on the analyzed hawthorn species and, according to PCA analysis, on the content of flavan-3-ols. These discoveries provided the theoretical basis for the possibility of industrial use of hawthorn seeds.

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来源期刊
Plant Foods for Human Nutrition
Plant Foods for Human Nutrition 工程技术-食品科技
CiteScore
6.80
自引率
7.50%
发文量
89
审稿时长
12-24 weeks
期刊介绍: Plant Foods for Human Nutrition (previously Qualitas Plantarum) is an international journal that publishes reports of original research and critical reviews concerned with the improvement and evaluation of the nutritional quality of plant foods for humans, as they are influenced by: - Biotechnology (all fields, including molecular biology and genetic engineering) - Food science and technology - Functional, nutraceutical or pharma foods - Other nutrients and non-nutrients inherent in plant foods
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