纳米otheranostics 在癌症应用中的最新进展。

Suphiya Parveen, R Abira, Safal Paikray, Liza Sahoo, Nigam Sekahr Tripathy, Fahima Dilnawaz
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摘要

纳米医学领域显示出在单一平台上同时提供治疗和诊断(治疗)化合物的广阔前景。纳米治疗学具有令人难以置信的前景,因为它能同时进行非侵入性疾病检测和治疗,并能实时跟踪药物的释放和分布,从而预测和评估疗效。癌症治疗方法能安全有效地改善癌症预后。磁性纳米粒子、量子点、上转换纳米粒子、介孔二氧化硅纳米粒子、碳基纳米粒子和有机染料基纳米粒子等常见的纳米级生物材料已显示出巨大的治疗活性潜力。改善疾病检测和提高化疗效果的需求,以及对可临床转化的纳米材料的现实考虑,将成为近期治疗剂研究的关键驱动因素。精确治疗纳米材料的开发应用于成像系统,如具有多功能能力的 MRI、PET 和 SPECT。本综述讨论了用于/开发治疗活性的不同纳米颗粒/纳米材料。
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Recent Advancement of Nanotheranostics in Cancer Applications.

The field of nanomedicine shows promising implications in the concurrent delivery of therapeutic and diagnostic (theranostics) compounds in a single platform. Nanotheranostics is incredibly promising since it offers simultaneous non-invasive disease detection and treatment together with the exciting ability to track drug release and distribution in real-time, thereby forecasting and evaluating the efficacy of the therapy. The cancer theranostic approach improves the cancer prognosis safely and effectively. Common classes of nanoscale biomaterials, including magnetic nanoparticles, quantum dots, upconversion nanoparticles, mesoporous silica nanoparticles, carbon- based nanoparticles, and organic dye-based nanoparticles, have demonstrated enormous potential for theranostic activity. The need for improved disease detection and enhanced chemotherapeutic treatments, together with realistic considerations for clinically translatable nanomaterials will be key driving factors for theranostic agent research shortly. The developments of precision theranostic nanomaterials are employed in imaging systems like, MRI, PET, and SPECT with multifunctional ability. In this review, different nanoparticles/nanomaterials that are used/developed for theranostic activity are discussed.

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